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United States

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Cat. No.: HY-P11657

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GN-2 peptoid

GN-2 peptoid is a 9-mer cationic amphipathic peptoid and bactericidal agent with an overall net charge of +4, broad-spectrum antimicrobial activity, and low hemolytic and cytotoxic activity against mammalian cells. GN-2 peptoid exerts bactericidal action against Escherichia coli in a concentration-dependent manner. GN-2 peptoid exhibits antimicrobial activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, Pseudomonas aeruginosa strains. GN-2 peptoid shows low toxicity against human red blood cells and HeLa cells. GN-2 peptoid maintains antimicrobial activity in the presence of 50% human blood plasma. GN-2 peptoid can be used for the research of bacterial infections.

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CAS No.: 1805781-73-0
화학식: C₇₈H₁₁₀N₁₈O₉
분자량:1443.82

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

GN-2 peptoid Chemical Structure

CAS No.: 1805781-73-0

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

GN-2 peptoid exhibits a MIC of 3.13 μg/mL against both Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (PAO1), and a MIC of 6.25 μg/mL against Escherichia coli. It possesses moderate antibacterial activity (SR=4-32) and shows no hemolytic activity (>128 μg/mL)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Hela WT cell
Concentration:

47 μg/mL
Incubation Time:

/
Result:

Showed cytotoxicity against human cells.

Related Protocols :

Chemical Information

CAS No. 1805781-73-0
분자량 1443.82
화학식 C₇₈H₁₁₀N₁₈O₉
Sequence

{Nlys}-{Ntrp}-{Nlys}-{Nlys}-{Ntrp}-{Ntrp}-{Nlys}-{Ntrp}-{Nile}-NH2
Sequence Shortening

{Nlys}-{Ntrp}-{Nlys}-{Nlys}-{Ntrp}-{Ntrp}-{Nlys}-{Ntrp}-{Nile}-NH2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mojsoska B, et al. Structure-activity relationship study of novel peptoids that mimic the structure of antimicrobial peptides. Antimicrob Agents Chemother. 2015;59(7):4112-4120. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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