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Cat. No.: HY-170598

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HP211206

고객리뷰

Based on 1 Customer Validation

HP211206 is a SARS-CoV-2 main protease (M^pro) PROTAC degrader. HP211206 effectively degrades SARS-CoV-2 M^pro and its drug-resistant mutants. HP211206 has an IC₅₀ of 181.9 nM and a DC₅₀ of 621 nM for M^pro. HP211206 has antiviral activity.
(Pink: SARS-CoV-2 Mpro ligand (HY-170599); Blue: Cereblon ligand (HY-41547); Black: linker (HY-B0236)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3119106-17-8
화학식: C₄₂H₅₅F₂N₉O₁₀
분자량:883.94

보관:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Data Sheet (266 KB)

HP211206 Chemical Structure

CAS No.: 3119106-17-8

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

HP211206 is a SARS-CoV-2 main protease (M^pro) PROTAC degrader. HP211206 effectively degrades SARS-CoV-2 M^pro and its drug-resistant mutants. HP211206 has an IC₅₀ of 181.9 nM and a DC₅₀ of 621 nM for M^pro. HP211206 has antiviral activity^[1]. (Pink: SARS-CoV-2 Mpro ligand (HY-170599); Blue: Cereblon ligand (HY-41547); Black: linker (HY-B0236)).

IC₅₀ & Target

IC₅₀: 181.9 nM (SARS-CoV-2 M^pro);
DC₅₀: 621 nM (SARS-CoV-2 M^pro)^[1].

All PROTACs Isoforms :

Chemical Information

CAS No. 3119106-17-8
Appearance Solid
분자량 883.94
화학식 C₄₂H₅₅F₂N₉O₁₀
Color Light yellow to green yellow
SMILES

O=C(CCC1N2C(C(C(NCCCCCC(N(C)[C@@H](C)C(N[C@@H](C(C)(C)C)C(N3[C@H](C(N[C@H](C#N)C[C@H]4C(NCC4)=O)=O)C[C@@H](OC(F)F)C3)=O)=O)=O)=CC=C5)=C5C2=O)=O)NC1=O
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sang X, et al. A Chemical Strategy for the Degradation of the Main Protease of SARS-CoV-2 in Cells. J Am Chem Soc. 2023 Dec 20;145(50):27248-27253. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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Purity:
수량:

HP211206

All PROTACs Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HP211206 Related Classifications

HY-170598 Related Classifications