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Cat. No.: HY-E72110

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Human UGT1A8

Human UGT1A8 is a UDP-glucuronosyltransferase. Human UGT1A8 catalyzes the transfer of glucuronosyl group from UDPGA to Dihydrotestosterone, forming DHT monoglucuronide. Human UGT1A8 catalyzes the transfer of glucuronosyl group from UDPGA to DHT monoglucuronide, introducing a second glucuronosyl group at the C2^' position of the latter to form DHT diglucuronide. Human UGT1A8 catalyzes the glucuronidation reactions of coumarins, anthraquinones, flavonoids, phenolic compounds, catechol estrogens, primary amines including 4-Aminobiphenyl, and some opioids.

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보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Human UGT1A8 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

UGT1A8

In Vitro

Human UGT1A8 (20 μM DHT; 30 min) catalyzes the monoglucuronidation of dihydrotestosterone, with an enzymatic activity of 127 pmol/min/mg protein^[1].
Human UGT1A8 (240 min) catalyzes the diglucuronidation reaction of DHT monoglucuronide, with an activity of 0.047 pmol/min/mg protein^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[Human UGT1A8]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Murai T, et al. Human UDP-glucuronosyltransferase, UGT1A8, glucuronidates dihydrotestosterone to a monoglucuronide and further to a structurally novel diglucuronide. Drug metabolism and disposition: the biological fate of chemicals. 2006 Jul;34(7):1102-8. [Content Brief]

[2]. Cheng Z, et al. Cloning and expression of human UDP-glucuronosyltransferase (UGT) 1A8. Arch Biochem Biophys. 1998 Aug 15;356(2):301-5. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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