IACS-8803
Based on 2 publication(s) in Google Scholar
IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy.
The free form of the compound is prone to instability, it is advisable to consider the stable salt form (IACS-8803 disodium and IACS-8803 diammonium) that retains the same biological activity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 2095690-70-1
- 화학식: C20H23FN10O9P2S2
- 분자량:692.53
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Other In-stock Forms of IACS-8803
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
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HY-112693
H-151STING Antagonist -
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C-176STING Inhibitor -
HY-136927
MSA-2STING Agonist -
HY-112921A
diABZI STING agonist-1STING Agonist -
HY-112921B
diABZI STING agonist-1 trihydrochlorideSTING Receptor Agonist -
HY-131454
SR-717STING Agonist -
HY-145010
SN-011STING Inhibitor -
HY-12885B
2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium saltSTING Agonist -
HY-107780B
Cyclic-di-GMP diammoniumSecond Messenger/STING Agonist -
HY-138682
STING-IN-2STING Inhibitor -
HY-111999A
E7766 diammonium saltSTING Agonist -
HY-123963
C-178STING Inhibitor
Publications Citing Use of MedChemExpress (MCE) IACS-8803
More
Biological Activity
제품 설명
IC50 & Target
STING[1]
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2095690-70-1
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Appearance Solid
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분자량 692.53
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화학식 C20H23FN10O9P2S2
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Color White to yellow
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](F)[C@H](O[P@@]4(S)=O)[C@@H](CO[P@](O[C@@H]5[C@H](O)[C@@H](CO4)O[C@H]5N(C=N6)C7=C6C(N)=NC=N7)(S)=O)O3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Clin Cancer Res
Cryoablation Does Not Significantly Contribute to Systemic Effector Immune Responses in a Poorly Immunogenic B16F10 Melanoma Model. [Abstract]2024 Sep 13;30(18):4190-4200. PMID: 39024020 -
Res Sq
DNA-PKcs inhibition sensitizes glioblastoma to radiotherapy through reprogramming of tumor cell states and immune microenvironment cell types. [Abstract]2026 Jun 5:rs.3.rs-9657955. PMID: 42281979
용액&용해도
In Vitro:
H2O : 15 mg/mL (21.66 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
순도&문서
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.4440 mL | 7.2199 mL | 14.4398 mL | 36.0995 mL |
| 5 mM | 0.2888 mL | 1.4440 mL | 2.8880 mL | 7.2199 mL | |
| 10 mM | 0.1444 mL | 0.7220 mL | 1.4440 mL | 3.6100 mL | |
| 15 mM | 0.0963 mL | 0.4813 mL | 0.9627 mL | 2.4066 mL | |
| 20 mM | 0.0722 mL | 0.3610 mL | 0.7220 mL | 1.8050 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
IACS-8803 Related Classifications
HY-130115 Related Classifications
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