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Cat. No.: HY-139663

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IHVR-17028

고객리뷰

Based on 1 Customer Validation

IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC₅₀ values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC₅₀ of 0.24 μM. IHVR-17028 can be used for infectious diseases research.

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Purity: 99.61%
CAS No.: 1428247-78-2
화학식: C₂₃H₄₄N₂O₅
분자량:428.61

보관:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

IHVR-17028 Chemical Structure

CAS No.: 1428247-78-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	500 μM Compound: 24	Cytotoxicity against human Huh7.5 cells by MTT assay Cytotoxicity against human Huh7.5 cells by MTT assay	[PMID: 23453839]
Huh-7	CC₅₀	500 μM Compound: 3	Cytotoxicity against human Huh7.5 cells by MTT assay Cytotoxicity against human Huh7.5 cells by MTT assay	[PMID: 23747225]
Huh-7	EC₅₀	0.2 μM Compound: 3	Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis	[PMID: 23747225]
Huh-7	EC₅₀	0.2 μM Compound: 24	Antiviral activity against Tacaribe virus infected in human Huh7.5 cells Antiviral activity against Tacaribe virus infected in human Huh7.5 cells	[PMID: 23453839]

In Vitro

In virus yield reduction assays, IHVR-17028 inhibits viral activities with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM for bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), DENV (serotype 2, New Guinea C), respectively. And in MTT assays, IHVR-17028 exhibits IC₅₀ values of all >500 μM in?MDBK, Huh7.5 or BHK cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In Pharmacokinetic analysis in rats, IHVR17028 (oral gavage; 75 mg/kg) shows a C_max?value of 0.18 μg/ml; the Tmax value is 1.56 hours; and the F% value is 12% after PO administration, the T_1/2 value is 0.88 hour after iv. adminstration^[1].
IHVR-17028 (oral gavage; 25-50 mg/kg; treatment 1 day prior to virus challenging) exhibits significant protection in mouse model of lethal MARV infection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice are challenged with 1,000 PFU mouse adapted MARV via IP injection^[1]
Dosage:

50 mg/kg
Administration:

Treatment 1 day prior to virus challenging
Result:

Exhibited protection in mouse when the treatment is initiated 1 day prior to virus challenging.

Animal Model:

C57B1/6 mice challenged with 1,000 PFU mouse adapted EBOV^[1]
Dosage:

25 mg/kg
Administration:

Twice daily at 12 h interval; starting 4 h post infection for 10 days
Result:

Inhibited EBOV infection in mice.

Chemical Information

CAS No. 1428247-78-2
Appearance Oil
분자량 428.61
화학식 C₂₃H₄₄N₂O₅
Color Colorless to light yellow
SMILES

OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCN(C(C(C)(C)C)=O)C2CCCCC2
선적

Room temperature in continental US; may vary elsewhere.

보관

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jinhong Chang, et al. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses.Antiviral Res. 2013 Jun;98(3):432-40. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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IHVR-17028

MCE Bioactive Compound Library

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

IHVR-17028 Related Classifications

HY-139663 Related Classifications