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Cat. No.: HY-123592

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INK4C-IN-3

INK4C-IN-3 is a synthetic coumarin amide compound and a small-molecule inhibitor of INK4C (p18INK4C). INK4C-IN-3 promotes the ex vivo expansion of human and mouse hematopoietic stem cells. INK4C-IN-3 can be used in research related to hematopoietic stem cell expansion.

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CAS No.: 1111287-26-3
화학식: C₁₉H₁₆N₂O₄
분자량:336.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

INK4C-IN-3 Chemical Structure

CAS No.: 1111287-26-3

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

INK4C-IN-3 (compound 41) (administered continuously for 14 days) potently promotes the expansion of murine C57BL/6 CD34⁻LKS hematopoietic stem cells in vitro, with an ED₅₀ of 9.92 nM^[2].
INK4C-IN-3 (0.01-1 μM; 7 days) promotes the ex vivo expansion of human umbilical cord blood CD34⁺ hematopoietic stem cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

human umbilical cord blood CD34+ hematopoietic stem cells
Concentration:

0.01, 0.1, 1 μM
Incubation Time:

7 days
Result:

Promoted the ex vivo expansion of human umbilical cord blood CD34⁺ hematopoietic stem cells.

Chemical Information

CAS No. 1111287-26-3
분자량 336.34
화학식 C₁₉H₁₆N₂O₄
SMILES

O=C(C1=CC=C(C=C1)NC(C)=O)NC2=CC(OC3=O)=C(C(C)=C3)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ronad PM, et al. Synthesis and evaluation of anti-inflammatory and analgesic activities of a novel series of substituted-N-(4-methyl-2-oxo-2H-chromen-7-yl) benzamides. Arzneimittelforschung. 2008;58(12):641-6. [Content Brief]

[2]. Xie XQ, et al. Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Scientific reports. 2015 Dec 18;5:18115. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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