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Cat. No.: HY-176708

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ISM5939

고객리뷰

Based on 1 Customer Validation

ISM5939 is an orally active and selective ENPP1 inhibitor with an IC₅₀ of 0.63 nM for 2,3-cGAMP degradation and 9.28 nM for ATP hydrolysis. ISM5939 has antitumor activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.79%
CAS No.: 2965301-60-2
화학식: C₂₀H₁₈FN₅O₃S
분자량:427.45

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ISM5939 Chemical Structure

CAS No.: 2965301-60-2

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Parmacokinetics
- Clinical Trial
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

ISM5939 is an orally active and selective ENPP1 inhibitor with an IC₅₀ of 0.63 nM for 2,3-cGAMP degradation and 9.28 nM for ATP hydrolysis. ISM5939 has antitumor activity^[1].

All Phosphodiesterase (PDE) Isoforms :

Parmacokinetics

Species	Dose	Route	Bioavailability	Clearance (CL)	V_ss
Mice^[1]	1 mg/kg	i.v.	32 %	14 mL/min/kg	0.53 L/kg
Mice^[1]	5 mg/kg	p.o.	32 %	14 mL/min/kg	0.53 L/kg
Mice^[1]	1 mg/kg	i.v.	49 %	14 mL/min/kg	1.1 L/kg
Mice^[1]	5 mg/kg	p.o.	49 %	14 mL/min/kg	1.1 L/kg
Mice^[1]	0.5 mg/kg	i.v.	45 %	2.0 mL/min/kg	0.63 L/kg
Mice^[1]	1 mg/kg	p.o.	45 %	2.0 mL/min/kg	0.63 L/kg

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 2965301-60-2
Appearance Solid
분자량 427.45
화학식 C₂₀H₁₈FN₅O₃S
Color White to off-white
SMILES

COC1=C(C2=CC=CC=C2)C3=C(C=N1)N=C(C)N3CC4=C(F)C=C(S(N)(=O)=O)C=N4
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 200 mg/mL (467.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3395 mL

11.6973 mL

23.3945 mL

5 mM

0.4679 mL

2.3395 mL

4.6789 mL

10 mM

0.2339 mL

1.1697 mL

2.3395 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pu C, et al. Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors. Nat Commun. 2025 May 23;16(1):4793. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3395 mL	11.6973 mL	23.3945 mL	58.4864 mL
	5 mM	0.4679 mL	2.3395 mL	4.6789 mL	11.6973 mL
	10 mM	0.2339 mL	1.1697 mL	2.3395 mL	5.8486 mL
	15 mM	0.1560 mL	0.7798 mL	1.5596 mL	3.8991 mL
	20 mM	0.1170 mL	0.5849 mL	1.1697 mL	2.9243 mL
	25 mM	0.0936 mL	0.4679 mL	0.9358 mL	2.3395 mL
	30 mM	0.0780 mL	0.3899 mL	0.7798 mL	1.9495 mL
	40 mM	0.0585 mL	0.2924 mL	0.5849 mL	1.4622 mL
	50 mM	0.0468 mL	0.2339 mL	0.4679 mL	1.1697 mL
	60 mM	0.0390 mL	0.1950 mL	0.3899 mL	0.9748 mL
	80 mM	0.0292 mL	0.1462 mL	0.2924 mL	0.7311 mL
	100 mM	0.0234 mL	0.1170 mL	0.2339 mL	0.5849 mL

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- Clinical Trial
Chemical Information
용액&용해도
- In Vitro
순도&문서
References

상품명:
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수량:
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상품명:
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ISM5939

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Small Molecule Immuno-Oncology Compound Library

Pyroptosis Compound Library

Orally Active Compound Library

Anti-Alzheimer's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Anti-Colorectal Cancer Compound Library

Metabolic Enzyme Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Immunopotentiator Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

ISM5939

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Small Molecule Immuno-Oncology Compound Library

Pyroptosis Compound Library

Orally Active Compound Library

Anti-Alzheimer's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Anti-Colorectal Cancer Compound Library

Metabolic Enzyme Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Immunopotentiator Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

ISM5939 Related Classifications

HY-176708 Related Classifications