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Cat. No.: HY-14509

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LP-661438

LP-661438 (Compound 10) is an orally active DCK inhibitor (IC₅₀ = 1.7 nM). LP-661438 inhibits deoxycytidine kinase in T cells and in vivo.

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CAS No.: 1034174-88-3
화학식: C₂₃H₂₀FN₅O₂S
분자량:449.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

LP-661438 Chemical Structure

CAS No.: 1034174-88-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

LP-661438 (Compound 10) is an orally active DCK inhibitor (IC₅₀ = 1.7 nM). LP-661438 inhibits deoxycytidine kinase in T cells and in vivo^[1].

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
T-cell	EC₅₀	17 nM Compound: 10	Inhibition of deoxycytidine kinase in anti CD3 and anti CD28 -stimulated human T cells assessed as reduction in [3H]deoxycitidine incorporation Inhibition of deoxycytidine kinase in anti CD3 and anti CD28 -stimulated human T cells assessed as reduction in [3H]deoxycitidine incorporation	[PMID: 19836232]
T-cell	EC₅₀	90 nM Compound: 10	Inhibition of deoxycytidine kinase in anti CD3 and anti CD28 -stimulated mouse T cells assessed as reduction in [3H]deoxycitidine incorporation Inhibition of deoxycytidine kinase in anti CD3 and anti CD28 -stimulated mouse T cells assessed as reduction in [3H]deoxycitidine incorporation	[PMID: 19836232]

Chemical Information

CAS No. 1034174-88-3
분자량 449.50
화학식 C₂₃H₂₀FN₅O₂S
SMILES

O=C(N[C@H]1CC[C@H](N2C(N=C(N)C(F)=C2)=O)C1)C3=NC=CC(C4=CC5=CC=CC=C5S4)=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jessop TC, et al. Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6784-7. d [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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LP-661438

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

LP-661438 Related Classifications

HY-14509 Related Classifications