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Cat. No.: HY-122164

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LY-503430

LY-503430 is an orally active AMPA receptor positive allosteric modulator (PAM). LY-503430 can be used for the study of Parkinson's disease.

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CAS No.: 625820-83-9
화학식: C₂₀H₂₅FN₂O₃S
분자량:392.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

LY-503430 Chemical Structure

CAS No.: 625820-83-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

LY-503430 is an orally active AMPA receptor positive allosteric modulator (PAM). LY-503430 can be used for the study of Parkinson's disease^[1].

All iGluR Isoforms :

In Vitro

The submicromolar concentrations of LY-503430 (0.03-10 μM) selectively enhances glutamate-induced calcium influx into human embryonic kidney 293 cells transfected with human GLUA1, GLUA2, GLUA3, or GLUA4 AMPA receptors. LY-503430 also potentiates AMPA-mediated responses in native cortical, hippocampal, and substantia nigra neurons^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LY503430 (0.5 mg/kg; s.c; once a day; for 11 days) has functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57Bl6J mice (20-25 g) injected with MPTP (HY-15608)^[1]
Dosage:

0.5 mg/kg
Administration:

s.c; once a day; for 11 days
Result:

Prevention of MPTP-induced neurotoxicity in mice.

Related Protocols :

Human pluripotent stem cell midbrain dopaminergic neuron differentiation

Chemical Information

CAS No. 625820-83-9
분자량 392.49
화학식 C₂₀H₂₅FN₂O₃S
SMILES

O=C(C1=CC=C(C2=CC=C([C@](C)(F)CNS(=O)(C(C)C)=O)C=C2)C=C1)NC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tracey K Murray, et al. LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease. J Pharmacol Exp Ther. 2003 Aug;306(2):752-62. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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