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Cat. No.: HY-159178

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m-AM-BBIQ

m-AM-BBIQ (compound 10) is a dual TLR7 and TLR8 agonist, with EC₅₀ values of 0.12 μM and 1.7 μM for hTLR7 and hTLR8, respectively.

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CAS No.: 1258457-58-7
화학식: C₂₂H₂₅N₅
분자량:359.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

m-AM-BBIQ Chemical Structure

CAS No.: 1258457-58-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

m-AM-BBIQ (compound 10) is a dual TLR7 and TLR8 agonist, with EC₅₀ values of 0.12 μM and 1.7 μM for hTLR7 and hTLR8, respectively^[1].

All Toll-like Receptor (TLR) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	14 nM Compound: 2	Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay	[PMID: 26351878]

Chemical Information

CAS No. 1258457-58-7
분자량 359.47
화학식 C₂₂H₂₅N₅
SMILES

NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3CC4=CC=CC(CN)=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kushvinder Kumar, et al. Modulation of the Adjuvant Potential of Imidazoquinoline-Based TLR7/8 Agonists via Alum Adsorption. ACS Med. Chem. Lett. 2024, July. 22.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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m-AM-BBIQ

All Toll-like Receptor (TLR) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

m-AM-BBIQ Related Classifications

HY-159178 Related Classifications