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Cat. No.: HY-120704

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Mps-BAY2b

Mps-BAY2b is a oral active monopolar spindle 1 (MPS1) inhibitor with the IC₅₀ of 14 nM (human MPS1). Mps-BAY2b shows anticancer activity and can be used for study of cancer.

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CAS No.: 1263420-68-3
화학식: C₂₀H₂₃N₅O
분자량:349.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Mps-BAY2b Chemical Structure

CAS No.: 1263420-68-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Mps-BAY2b is a oral active monopolar spindle 1 (MPS1) inhibitor with the IC₅₀ of 14 nM (human MPS1). Mps-BAY2b shows anticancer activity and can be used for study of cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	670 nM Compound: 5; Mps-BAY2b	Inhibition of MPS1 in human HeLa cells assessed as reduction in spindle assembly checkpoint incubated for 4 hrs by p-histone H3/Hoechst 33342 staining based microscopic analysis Inhibition of MPS1 in human HeLa cells assessed as reduction in spindle assembly checkpoint incubated for 4 hrs by p-histone H3/Hoechst 33342 staining based microscopic analysis	[PMID: 32338514]

Chemical Information

CAS No. 1263420-68-3
분자량 349.43
화학식 C₂₀H₂₃N₅O
SMILES

O=C(NC1CC1)C2=CC=C(C3=CN=C4C(NCC(C)C)=NC=CN43)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jemaà M, et al. Characterization of novel MPS1 inhibitors with preclinical anticancer activity. Cell Death Differ. 2013 Nov;20(11):1532-45. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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