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Cat. No.: HY-149410

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MSN8C

MSN8C, an analog of mansonone E, is a novel catalytic inhibitor of human DNA topoisomerase II. MSN8C induces cancer cell apoptosis. MSN8C shows significant anti-tumor cell proliferation activity in vitro.

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CAS No.: 1314798-31-6
화학식: C₁₃H₁₀O₃
분자량:214.22

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

MSN8C Chemical Structure

CAS No.: 1314798-31-6

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CNE-2	IC₅₀	2.05 μM Compound: 7	Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay	[PMID: 21600681]

In Vitro

MSN8C prevents supercoiled DNA from entering the catalytic cycle to avoid capture by Topo II poisons and reduces fragmented DNA generation^[1].
MSN8C (1-10 μM, 24 h) induces HL-60 cancer cell apoptosis via increases caspases-3 expression in a dose-dependent manner.^[1].
MSN8C (1, 5, 10, 20 μM, 12 h) increases caspase-8 and caspase-9 activity in HL-60 cells^[1].
MSN8C (48 h) inhibits human 11 tumor cell lines from various origins with an average IC₅₀ value of 2.6 µM^[1].
MSN8C has strong antiproliferative effects on the human breast cancer adriamycin (HY-15142)-resistant cell line MCF-7/Adr and mitoxantrone (HY-13502)-resistant cell line HL-60/MX2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HL-60 cells
Concentration:

10 μM
Incubation Time:

1 h
Result:

Reduced γ-H2AX expression levels.
Weakened the production of γ-H2AX by VP-16.

Western Blot Analysis^[1]

Cell Line:

HL-60 cells
Concentration:

1, 5, 10, 20 μM
Incubation Time:

1, 5, 10, 20 μM
Result:

Induced caspases-3 express in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

HL-60 cells
Concentration:

5, 10 μM
Incubation Time:

12 h
Result:

Promoted caspase-8 and caspase-9 activity in a dose-dependent manner.

In Vivo

MSN8C (10 mg/kg, i.p, two-day intervals for 2 weeks) in a A549 tumor xenograft model inhibits tumor growth with less toxic^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

A549 tumor xenograft model, female BALB/c nude mice^[1]
Dosage:

10 mg/kg
Administration:

Intraperitoneal injection (i.p.), two-day intervals for 2 weeks
Result:

Inhibits tumor with the tumor weight inhibition (TWI) value of 74.2%.

Chemical Information

CAS No. 1314798-31-6
분자량 214.22
화학식 C₁₃H₁₀O₃
SMILES

CC(CO1)C2=C(C1=CC(C3=O)=O)C3=CC=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jie-Bin Ou, et al. MSN8C: A Promising Candidate for Antitumor Applications as a Novel Catalytic Inhibitor of Topoisomerase II. Molecules. 2023 Jul, 28(14).

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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Cat. No.:
수량:
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MSN8C

All Topoisomerase Isoforms