country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-106111

Copy Link Print Information

Nafagrel

Name: Nafagrel
Brand: MedChemExpress
SKU: HY-106111
Availability: PreOrder

(Synonyms: DP-1904 free acid)

Nafagrel (DP-1904 free acid) is a Thromboxane A₂ synthase inhibitor. Nafagrel inhibits the production of Thromboxane A₂ and increases the production of Prostaglandin I₂ (HY-A0126A). Nafagrel prevents thrombotic material accumulation in acute arterial thrombosis models. Nafagrel can be used in research on peripheral vascular disease, restenosis after PTCA, and lupus nephritis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 97901-21-8
화학식: C₁₅H₁₆N₂O₂
분자량:256.31

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nafagrel Chemical Structure

CAS No.: 97901-21-8

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Prostaglandin Receptor Isoforms :

In Vitro

Lipid Inflammatory MediatorsLocal Vascular RegulationOthers

Lipid Inflammatory Mediators

Local Vascular Regulation

DP-1904 (0.1 μM-1 mM; 2 h) completely suppresses TXB₂ production and dramatically increases 6-keto-PGF_1α production from human umbilical vein EC and platelets stimulated by HA-IgG in a coculture system, acting as a TXA₂ synthetase inhibitor^[3].

Others

Nafagrel inhibits thromboxane synthase as an imidazole derivative^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[3]

Cell Line:

Human umbilical vein endothelial cells and human platelets
Concentration:

10^-3, 10^-4, 10^-5, 10^-6, 10^-7 M
Incubation Time:

2 h
Result:

Suppressed TXB2 production at 10^-3 to 10^-6 M to levels similar to controls.
Increased 6-keto-PGF1α production at 10^-4 to 10^-7 M.
Decreased the TXB2/6-keto-PGF1α ratio at all concentrations.

In Vivo

Local Vascular Regulation

Nafagrel inhibits the accumulation of thrombotic material in a rat model of acute arterial thrombosis, whereas ASA is ineffective^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Cardiovascular Diseases

Chemical Information

CAS No. 97901-21-8
분자량 256.31
화학식 C₁₅H₁₆N₂O₂
SMILES

O=C(O)C1=CC=C2C(=C1)CCC(C2)CN3C=NC=C3
Synonyms

DP-1904 free acid
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Geiger J, et al. Inhibitors of platelet signal transduction as anti-aggregatory drugs. Expert opinion on investigational drugs. 2001 May;10(5):865-90. [Content Brief]

[2]. Herrman J P R, et al. Pharmacological approaches to the prevention of restenosis following angioplasty: the search for the Holy Grail?(Part I)[J]. Drugs, 1993, 46(1): 18-52.

[3]. Kaneko N, et al. Production of thromboxane A2 and prostaglandin i2 affected by interaction of heat aggregated IgG, endothelial cells, and platelets in lupus nephritis. The Journal of rheumatology. 2002 Oct;29(10):2106-13.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기