country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182646

Copy Link Print Information

NE-10133

NE-10133 is a I_SK and I_KS potassium channel (Potassium Channel) inhibitor. NE-10133 inhibits voltage-dependent and slowly activated delayed rectifier potassium currents. NE-10133 exhibits class III antiarrhythmic activity. NE-10133 is applicable for research related to arrhythmias.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 149889-02-1
화학식: C₂₃H₃₀Cl₃N₅O₄
분자량:546.87

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NE-10133 Chemical Structure

CAS No.: 149889-02-1

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

NE-10133 potently inhibits rat I_SK channels expressed in Xenopus oocytes, with an EC₅₀ of 12 μM; at concentrations up to 20 μM, it exerts no effect on RBK1, RBK2 or RGK5 potassium channels^[2].
NE-10133 potently inhibits the I_Ks potassium current in guinea pig ventricular myocytes with an EC₅₀ of 11 μM, and its efficacy is comparable to its inhibitory effect on rat I_SK channels in Xenopus oocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 149889-02-1
분자량 546.87
화학식 C₂₃H₃₀Cl₃N₅O₄
SMILES

O=C1N(CC(N1CCCN2CCN(CC2)CCO)=O)/N=C/C3=CC=C(C4=CC=C(Cl)C=C4)O3.Cl.Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Bao JJ, et al. Separation and quantitation of azimilide and its putative metabolites by capillary electrophoresis. J Chromatogr B Biomed Sci Appl. 1998;720(1-2):129-140. [Content Brief]

[2]. Busch AE, et al. The novel class III antiarrhythmics NE-10064 and NE-10133 inhibit IsK channels expressed in Xenopus oocytes and IKs in guinea pig cardiac myocytes. Biochem Biophys Res Commun. 1994;202(1):265-270. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유