NNMT-IN-6
NNMT-IN-6 is a selective nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.41 μM and a Kd of 5.55 μM. NNMT-IN-6 hydrochloride exhibits selectivity over PRMT1 and NSD2. NNMT-IN-6 inhibits cancer cell proliferation and reduces cellular N-methylnicotinamide (MNA) production. NNMT-IN-6 can be used for the research of oral cancer.
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- CAS No.: 2368247-39-4
- 화학식: C25H29N7O5
- 분자량:507.54
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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NNMT 1.41 μM (IC50) |
NNMT 5.55 μM (Kd) |
NNMT-IN-6 (compound 78) (10-100 μM; 24-72 h) dose- and time- dependently inhibits HSC-2 human oral cancer cell proliferation[1].
NNMT-IN-6 (100 μM; 0-72 h) inhibits cellular NNMT activity in HSC-2 human oral cancer cells, reducing MNA production by 50% at 100 μM after 48 h[1].
NNMT-IN-6 binds the NNMT active site, forms π-π stacking interactions with tyrosine residues in the nicotinamide binding pocket, and forms an intramolecular hydrogen bond that stabilizes its binding conformation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HSC-2 cells
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Concentration:1; 10; 50; 100 μM
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Incubation Time:24; 48; 72 h
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Result:Caused a significant 20% reduction in cell proliferation at 10 μM after 48 h.
Caused a significant 21% reduction in cell proliferation at 50 μM after 48 h.
Caused a significant 27% reduction in cell proliferation at 100 μM after 48 h.
Caused a significant 44% reduction in cell proliferation at 100 μM after 72 h.
Dose dependently inhibited HSC-2 cell proliferation.
Showed no inhibition activity at 24 h.
Chemical Information
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CAS No. 2368247-39-4
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분자량 507.54
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화학식 C25H29N7O5
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CN(CC(C=C4)=CC5=C4C=CC=C5)CC[C@@H](C(O)=O)N)O3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NNMT-IN-6 Related Classifications
HY-138993 Related Classifications
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