OXPHOS-IN-2

OXPHOS-IN-2 (Compound 28c) (0-1000 μM, 12 h) reduces the ratio of ATP and NAD⁺/NADH and inhibits AMPK phosphorylation in PC9 cells^[1].
OXPHOS-IN-2 (0-20 nM, 14 days) significantly inhibits the colony forming ability of PC9 cells^[1].
OXPHOS-IN-2 (0-1 μM) can induce apoptosis by dose dependently increasing reactive oxygen species (ROS) levels and reducing mitochondrial membrane potential in PC9 and Bxpc-3 cells^[1].
OXPHOS-IN-2 (0-50 nM) induces DNA damage and increases the expression of γ-H2AX in PC9 cells^[1].
OXPHOS-IN-2 can inhibit the proliferation of various tumor cell lines in glucose and galactose medium, including H1975 (IC₅₀ = 6.43 nM and 29.5 nM), H2228 (IC₅₀ = 4.54 nM and 21.5 nM), KP-4 (IC₅₀ = 3.61 nM and 48.7 nM), MKN45 (IC₅₀ = 5.78 nM and 29.8 nM), HCT116 (IC₅₀ = 5.19 nM and 31.2 nM), MDA-MB-231 (IC₅₀ = 1.31 nM and 7.5 nM), MHCC-97H (IC₅₀ = 1.76 nM and 12.4 nM) and SiHA (IC₅₀ = 5.10 nM and 35.1 nM) cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.