PE 22-28
Based on 1 Customer Validation
PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.98%
- CAS No.: 1801959-12-5
- 화학식: C35H55N11O9
- 분자량:773.88
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
IC50: 0.12 nM (TREK-1)[1]
PE 22-28 displays good specificity and affinity for TREK-1 channel with IC50 value of 0.12 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Naïve male C57Bl/6J mice[1]
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Dosage:3.0µg/kg
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Administration:Intraperitoneal
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Result:Showed a significant reduction of the immobility time, reduced significantly the latency to eat the food pellet, induced neurogenesis and improved the action duration.
Chemical Information
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CAS No. 1801959-12-5
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Appearance Solid
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분자량 773.88
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화학식 C35H55N11O9
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Color White to off-white
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Sequence
Gly-Val-Ser-Trp-Gly-Leu-Arg
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Sequence Shortening
GVSWGLR
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 50 mg/mL (64.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 21.7 mg/mL (28.04 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.2922 mL | 6.4609 mL | 12.9219 mL | 32.3047 mL |
| 5 mM | 0.2584 mL | 1.2922 mL | 2.5844 mL | 6.4609 mL | |
| 10 mM | 0.1292 mL | 0.6461 mL | 1.2922 mL | 3.2305 mL | |
| 15 mM | 0.0861 mL | 0.4307 mL | 0.8615 mL | 2.1536 mL | |
| 20 mM | 0.0646 mL | 0.3230 mL | 0.6461 mL | 1.6152 mL | |
| 25 mM | 0.0517 mL | 0.2584 mL | 0.5169 mL | 1.2922 mL | |
| DMSO | 30 mM | 0.0431 mL | 0.2154 mL | 0.4307 mL | 1.0768 mL |
| 40 mM | 0.0323 mL | 0.1615 mL | 0.3230 mL | 0.8076 mL | |
| 50 mM | 0.0258 mL | 0.1292 mL | 0.2584 mL | 0.6461 mL | |
| 60 mM | 0.0215 mL | 0.1077 mL | 0.2154 mL | 0.5384 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PE 22-28 Related Classifications
HY-P3581 Related Classifications
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