PEN (rat) TFA
PEN (rat) TFA, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.
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- 화학식: C104H170F3N27O35.xC2HF3O2
- 분자량:2301.59 (free base)
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Mouse PEN (mPEN) and rat PEN (rPEN) only differ by one residue at the N-terminal end, whereas human PEN (hPEN) is more divergent and has the sequence PEG instead of PEN[2].
PEN binds and activates a GPCR in the brain[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 2301.59 (free base)
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화학식 C104H170F3N27O35.xC2HF3O2
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Sequence
Ala-Val-Asp-Gln-Asp-Leu-Gly-Pro-Glu-Val-Pro-Pro-Glu-Asn-Val-Leu-Gly-Ala-Leu-Leu-Arg-Val
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Sequence Shortening
AVDQDLGPEVPPENVLGALLRV
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891. [Content Brief]
[2]. Ivone Gomes, et al. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PEN (rat) TFA Related Classifications
HY-P2277A Related Classifications
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