Penisimplicissin
Penisimplicissin is a funicone-like compound and antiviral agent. Penisimplicissin reduces the expression of AhR and viral nucleocapsid protein. Penisimplicissin improves the cell viability and morphological characteristics of CCoV-infected cells. Penisimplicissin inhibits CCoV infection. Penisimplicissin can be used in studies related to canine coronavirus infection.
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- CAS No.: 873207-55-7
- 화학식: C16H14O6
- 분자량:302.28
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Penisimplicissin (0.1-10 μM; 48 h) exhibits an IC50 of 4.9562 μM in canine fibrosarcoma A72 cells[1].
Penisimplicissin (0.1-2.5 μM; 48 h) significantly increases the cell viability of canine fibrosarcoma A72 cells infected with canine coronavirus (CCoV) after 48 h of treatment at concentrations of 0.5 μM and 2.5 μM[1].
Penisimplicissin (0.5 μM) reduces the morphological features of cell death in canine fibrosarcoma A72 cells infected with canine coronavirus (CCoV), including cell shrinkage, pyknosis, and cell detachment[1].
Penisimplicissin (0.5 μM; 48 h post-infection) significantly reduces viral yield and cytopathic effect in CCoV-infected canine fibrosarcoma A72 cells at 48 h post-treatment[1].
Penisimplicissin (0.5 μM; 24 h) significantly reduces the expression of aryl hydrocarbon receptor and viral nucleocapsid protein in both uninfected and CCoV-infected canine fibrosarcoma A72 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:canine fibrosarcoma A72 cells
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Concentration:0.1 μM, 0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM
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Incubation Time:48 h
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Result:Showed no significant difference in cell viability compared to vehicle control at 0.1, 0.5, and 2.5 μM (p > 0.05).
Significantly reduced cell viability at 1 μM (p < 0.05), 5 μM (p < 0.01), and 10 μM (p < 0.001).
Determined an IC50 of 4.9562 μM in A72 cells.
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Cell Line:canine fibrosarcoma A72 cells infected with canine coronavirus (CCoV)
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Concentration:0.1 μM, 0.5 μM, 2.5 μM
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Incubation Time:48 h post-infection
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Result:Showed no significant change in cell viability compared to untreated infected cells at 0.1 μM (p > 0.05).
Significantly increased cell viability in CCoV-infected A72 cells at 0.5 μM (p < 0.01) and 2.5 μM (p < 0.05).
Led to selection of the 0.5 μM dose for subsequent experiments.
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Cell Line:canine fibrosarcoma A72 cells infected with CCoV
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Concentration:0.5 μM
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Incubation Time:48 h post-infection
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Result:Caused a significant (p < 0.05) decrease in CCoV titer, measured as Log TCID50/mL, compared to untreated infected cells.
Resulted in a decreased cytopathic effect in treated cells relative to untreated infected cells.
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Cell Line:canine fibrosarcoma A72 cells (uninfected and CCoV-infected)
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Concentration:0.5 μM
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Incubation Time:24 h post-treatment (uninfected cells); 24 h post-infection (infected cells)
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Result:Caused a significant (p < 0.001) reduction in AhR expression in uninfected A72 cells compared to vehicle control.
Resulted in significant reductions in both AhR (p < 0.001) and viral NP (p < 0.001) expression in CCoV-infected A72 cells compared to untreated infected cells.
Chemical Information
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CAS No. 873207-55-7
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분자량 302.28
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화학식 C16H14O6
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SMILES
COC1=C2[C@H](C3=COC(C)=CC3=O)OC(C2=CC(OC)=C1)=O
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Structure Classification
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Initial Source
Talaromyces pinophilus
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Penisimplicissin Related Classifications
HY-182495 Related Classifications
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