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Cat. No.: HY-P3384

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Pezadeftide

Name: Pezadeftide
Brand: MedChemExpress
SKU: HY-P3384
Availability: PreOrder

(Synonyms: HXP124)

Pezadeftide (HXP124) is a naturally derived plant defensin peptide molecule with antifungal activity. Pezadeftide binds to fungal cell wall chitin and β-glucan, enters fungal cells via endocytosis; induces mitochondrial membrane hyperpolarization, promotes ROS generation, further triggers vacuole fusion, alters plasma membrane permeability, and ultimately causes fungal cell death. Pezadeftide exhibits inhibitory effects against various skin and nail pathogenic fungi. Pezadeftide can be used in research related to fungal infections.

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CAS No.: 1907724-92-8
화학식: C₂₃₄H₃₇₂N₇₀O₆₆S₈
분자량:5478.41

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pezadeftide Chemical Structure

CAS No.: 1907724-92-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Fungal InfectionBacterial InfectionMitochondrial FunctionOxidative Stress

Fungal Infection

Pezadeftide exhibits inhibitory activity against multiple skin and nail pathogenic fungi; for Trichophyton rubrum IC₅₀ = 4.6 μg/mL, for Trichophyton mentagrophytes IC₅₀ = 8.4 μg/mL, for Candida auris IC₅₀ = 1.3 μg/mL, for Candida albicans IC₅₀ = 3.4 μg/mL, for Candida tropicalis IC₅₀ = 1.9 μg/mL^[1].
Pezadeftide selects resistant S. cerevisiae deletion strains enriched in mitochondrial respiration and sphingolipid biosynthesis, among which F1-F0 ATP synthase mutants exhibit higher tolerance^[2].
Pezadeftide permeabilizes the S. cerevisiae plasma membrane in a concentration-dependent manner, induces ROS, and hyperpolarizes the mitochondrial membrane potential in S. cerevisiae BY4741^[2].
Pezadeftide induces ROS at 3-7 min and triggers vacuolar fusion at 14-16 min^[2].

Fungal Infection

Bacterial Infection

Pezadeftide (Ppdef1) binds chitin and yeast β-glucan in cell-free polysaccharide-binding assays and inhibits fungal pathogens with IC₅₀ values of 1.3-42.7 µg/mL, showing no activity against the tested bacteria at concentrations up to 200 µg/mL^[2].

Fungal Infection

Mitochondrial Function

Pezadeftide (15 μM) induces mitochondrial membrane hyperpolarization in C. albicans/S. cerevisiae and binds/internalizes in T. rubrum, accompanied by increased mitochondrial membrane potential^[1].

Oxidative Stress

Fungal Infection

Pezadeftide induces ROS in C. albicans cells and increases ROS production in T. rubrum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 1907724-92-8
분자량 5478.41
화학식 C₂₃₄H₃₇₂N₇₀O₆₆S₈
Synonyms

HXP124
Sequence

Ala-Lys-Val-Cys-Thr-Lys-Pro-Ser-Lys-Phe-Phe-Lys-Gly-Leu-Cys-Gly-Thr-Asp-Gly-Ala-Cys-Thr-Thr-Ala-Cys-Arg-Lys-Glu-Gly-Leu-His-Ser-Gly-Tyr-Cys-Gln-Leu-Lys-Gly-Phe-Leu-Asn-Ser-Val-Cys-Val-Cys-Arg-Lys-His-Cys (Disulfide bridge:Cys4-Cys51,Cys15-Cys35,Cys21-Cys45,Cys25-Cys47)
Sequence Shortening

AKVCTKPSKFFKGLCGTDGACTTACRKEGLHSGYCQLKGFLNSVCVCRKHC (Disulfide bridge:Cys4-Cys51,Cys15-Cys35,Cys21-Cys45,Cys25-Cys47)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (331 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Van der Weerden NL, et al. Pezadeftide is a potent antifungal peptide with rapid fungicidial activity via a unique mechanism of action. J Am Acad Dermatol. 2022 Sep 1;87:Ab92.

[2]. Parisi K, et al. Hyperpolarisation of Mitochondrial Membranes Is a Critical Component of the Antifungal Mechanism of the Plant Defensin, Ppdef1. Journal of fungi (Basel, Switzerland). 2024 Jan 07;10(1):54.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
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Chemical Information
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Pezadeftide

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In Vitro

Chemical Information

순도&문서

References

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Pezadeftide

Biological Activity

제품 설명

In Vitro

Chemical Information

순도&문서

References

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Pezadeftide Related Classifications

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