Pezadeftide

Pezadeftide exhibits inhibitory activity against multiple skin and nail pathogenic fungi; for Trichophyton rubrum IC₅₀ = 4.6 μg/mL, for Trichophyton mentagrophytes IC₅₀ = 8.4 μg/mL, for Candida auris IC₅₀ = 1.3 μg/mL, for Candida albicans IC₅₀ = 3.4 μg/mL, for Candida tropicalis IC₅₀ = 1.9 μg/mL^[1].
Pezadeftide selects resistant S. cerevisiae deletion strains enriched in mitochondrial respiration and sphingolipid biosynthesis, among which F1-F0 ATP synthase mutants exhibit higher tolerance^[2].
Pezadeftide permeabilizes the S. cerevisiae plasma membrane in a concentration-dependent manner, induces ROS, and hyperpolarizes the mitochondrial membrane potential in S. cerevisiae BY4741^[2].
Pezadeftide induces ROS at 3-7 min and triggers vacuolar fusion at 14-16 min^[2].
Pezadeftide (Ppdef1) binds chitin and yeast β-glucan in cell-free polysaccharide-binding assays and inhibits fungal pathogens with IC₅₀ values of 1.3-42.7 µg/mL, showing no activity against the tested bacteria at concentrations up to 200 µg/mL^[2].
Pezadeftide (15 μM) induces mitochondrial membrane hyperpolarization in C. albicans/S. cerevisiae and binds/internalizes in T. rubrum, accompanied by increased mitochondrial membrane potential^[1].
Pezadeftide induces ROS in C. albicans cells and increases ROS production in T. rubrum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.