Pilsicainide
Pilsicainide (SUN 1165 free acid) is a potent sodium channel blocker and potent class Ic antiarrhythmic agent.
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- CAS No.: 88069-67-4
- 화학식: C17H24N2O
- 분자량:272.39
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
Pilsicainide (SUN 1165 free acid; 10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 μg/mL in levo-thyroxine (T4)-treated rat atrial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley (SD) rats weighing from 200 to 220 g, with levo-thyroxine (T4) treatment[1]
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Dosage:2 mg/kg
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Administration:Bolus injection into right external carotid vein within 2 minutes, once
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Result:Elongated the QT interval at 15 and 60 minutes after administration.
Shortened P wave and QRS complex durations.
Markedly decreased action potential amplitudes (APA) and Max dV/dt, and significantly lengthened the action potential durations.
Chemical Information
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CAS No. 88069-67-4
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분자량 272.39
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화학식 C17H24N2O
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SMILES
O=C(NC1=C(C)C=CC=C1C)CC23CCCN2CCC3
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Synonyms
SUN 1165 free base; Pilzicainide
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pilsicainide Related Classifications
HY-133715 Related Classifications
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