IgG2
Among human IgG subclasses, IgG2 ranks second in serum concentration and specializes in responses to encapsulated bacteria, being the dominant antibody raised against polysaccharide antigens such as the pneumococcal capsule. Compared with IgG1, its Fc region binds activating Fc gamma receptors and C1q weakly, and its shorter, more rigid hinge further limits effector recruitment, so IgG2 functions mainly through antigen neutralization and opsonic cooperation rather than direct cytolysis. Selective IgG2 deficiency is among the most common primary antibody deficiencies and predisposes to recurrent sinopulmonary infections, particularly in children. IgG2 is also a candidate Fc format when therapeutic antibodies must avoid effector activation.
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IgG2 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
