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Cat. No.: HY-142648A

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(R)-MLT-985

(R)-MLT-985 is the R configuration of MLT-985 (HY-142648). MLT-985 is a selective allosteric and orally active MALT1 inhibitor with an IC₅₀ value of 3 nM. MLT-985 can suppress cell growth and aberrant CARD11/BCL10/MALT1 complex signaling. MLT-985 can be used for the research of cancer, such as B cell malignancies.

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CAS No.: 1832577-07-7
화학식: C₁₇H₁₅Cl₂N₉O₂
분자량:448.27

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

(R)-MLT-985 Chemical Structure

CAS No.: 1832577-07-7

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

Chemical Information

CAS No. 1832577-07-7
분자량 448.27
화학식 C₁₇H₁₅Cl₂N₉O₂
SMILES

O=C(NC1=CC(Cl)=C(N2N=CC=N2)N=C1)NC3=C([C@H](OC)C)N4C(N=C3)=CC(Cl)=N4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Quancard J, et al. Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63(23):14594-14608. [Content Brief]

[2]. Sara Elgamal, et al. Development of ZE66-0205, a Novel MALT1 Degrader for Treatment of B-Cell Malignancies, Blood, Volume 144, Supplement 1, 2024, Page 2783, ISSN 0006-4971.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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