RN983
RN983 (Compound 1) is a highly selective Bruton's tyrosine kinase (Btk) inhibitor. RN983 inhibits IgG production in B-cells with an IC50 of 2.5 nM and PGD2 production from mast cells with an IC50 of 8.3 nM. RN983 is promising for research of asthma and other allergic diseases.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 1423129-83-2
- 화학식: C34H37FN8O3
- 분자량:624.71
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
Chemical Information
-
CAS No. 1423129-83-2
-
분자량 624.71
-
화학식 C34H37FN8O3
-
SMILES
O=C1C(NC2=NC=C(C3CCN(CC3)C)C=C2)=CC(C4=C(CO)C(N5N=CC6=C(C5=O)C(F)=CC(C(C)(C)C)=C6)=NC=C4)=NN1C
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Phillips JE, et al. Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma. J Aerosol Med Pulm Drug Deliv. 2016 Jun;29(3):233-41. [Content Brief]
[2]. Raman Mahadevan Iyer, et al. Inhibitors of bruton's tyrosine kinase. WO2014083026A1. 2014-06-05.
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RN983 Related Classifications
HY-117628 Related Classifications
Powered by Bioz