SBI-183
Based on 1 Customer Validation
SBI-183 is an orally active inhibitor of QSOX1 (Kd: 20 μM). SBI-183 suppresses the proliferative and invasive phenotype of renal cancer cell lines, including triple negative breast cancer cell line, lung adenocarcinoma cell line and pancreatic ductal adenocarcinoma. SBI-183 inhibits tumor growth in two human xenograft mouse models of renal cell carcinoma in vivo .
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.8%
- CAS No.: 625403-59-0
- 화학식: C18H20N2O2
- 분자량:296.36
-
보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
SBI-183 (6.25-50 μM, 15 min) inhibits the enzymatic activity of rQSOX1 in a dose-dependent manner[1].
SBI-183 inhibits proliferation of tumor cells, but does not kill fibroblasts or rapidly proliferating PBMC (0.625-20 μmol/L, 5 days), inhibits viability of 786-O, RCJ-41T2, and MDA-MB-231 with IC50s of 4.6 μM, 3.9 μM, and 2.4 μM, respectively (0.076 nM-40 μM, 72 h)[1].
SBI-183 (2.5-20 μM, 4-8 days) inhibits tumor invasion in both 2D and 3D models of 786-O, RCJ-41T2, MDA-MB-231, A549 and MIA PaCa2 dose-dependently[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:786-O, RCJ-41T2, MDA-MB-231, A549 和 MIA PaCa2
-
Concentration:0.625, 1.25, 2.5, 5, 10, 20 μM
-
Incubation Time:5 days
-
Result:Inhibited the growth of each tumor cell in a concentration-dependent manner.
-
Cell Line:786-O, RCJ-41T2, MDA-MB-231, A549 和 MIA PaCa2
-
Concentration:2.5, 5, 10, 20 μM
-
Incubation Time:4, 6, 8 days
-
Result:Reduced invasion through Matrigel in each cell line.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Human xenograft mouse models of renal cell carcinoma (786-O and RCJ-41T2)[1]
-
Dosage:400 μg/mouse/day (786-O); 100 mg/kg (RCJ-41T2)
-
Administration:Oral gavage (p.o.)
-
Result:Inhibited the growth of 786-O and RCJ-41T2 in vivo.
Reduced laminin-α4 deposition in RCJ-41T2 mouse xenografts.
Chemical Information
-
CAS No. 625403-59-0
-
Appearance Solid
-
분자량 296.36
-
화학식 C18H20N2O2
-
Color White to off-white
-
SMILES
O=C(C1=CC(OC)=CC=C1)NC2=CC=C(N3CCCC3)C=C2
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
-
Data Sheet (270 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SBI-183 Related Classifications
HY-165245 Related Classifications
Powered by Bioz