SHMT2-IN-1
SHMT2-IN-1 is a potent serine hydroxymethyltransferase 2 (SHMT2) inhibitor with an IC50 of 1.21 μM and a KD of 10.6 μM. SHMT2-IN-1 binds to the folate binding site of SHMT2. SHMT2-IN-1 also inhibits SHMT1 with an IC50 of 1.83 μM. SHMT2-IN-1 can inhibit cancer cells proliferation, migration and invasion. SHMT2-IN-1 can induce cells apoptosis and ROS production and cause G2/M phase arrest. SHMT2-IN-1 can be used for the research of cancer, such as esophageal cancer.
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- 화학식: C26H16ClN7O2S2
- 분자량:558.03
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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SHMT2 1.21 μM (IC50) |
Human SHMT1 1.83 μM (IC50) |
SHMT2-IN-1 (0.1-10 μM, 24 h) exhibits potent antiproliferative activity against esophageal cancer cells KYSE-450 and KYSE-70 with IC50 values of 1.62 μM and 1.18 μM respectively[1].
SHMT2-IN-1 (2.5-10 μM, 24 h) dose-dependently inhibits the migration and invasion of KYSE-450 and KYSE-70 cells[1].
SHMT2-IN-1 (2.5-7.5 μM, 24-72 h) induces apoptosis, ROS production and cause G2/M phase arrest in KYSE-450 and KYSE-70 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KYSE-450 and KYSE-70 cells
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Concentration:2.5, 5 and 7.5 μM
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Incubation Time:72 h
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Result:Increased apoptotic cells.
Upregulated Bax expression and downregulated Bcl-2, Pro-Caspase 3 and Pro-Caspase 9 expression.
Chemical Information
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Appearance Solid
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분자량 558.03
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화학식 C26H16ClN7O2S2
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Color White to off-white
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SMILES
N#CC1=C(N=C(N=C1C2=CC=C(C=C2)Cl)SCC3=CC=C(C=C3)C(O)=O)SC4=NN=NN4C5=CC=CC=C5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (274 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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