SPAA-52
Based on 1 Customer Validation
SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used in diabete research.
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- Purity : 97.07%
- CAS No.: 2837000-75-4
- 화학식: C8H8Br2N2O4S
- 분자량:388.03
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
IC50: 4 nM (LMW-PTP)[1]
In Vivo
| Compound | SPAA-52 | |
| dose route | 2 mg/kg IV | 10 mg/kg PO |
| AUC (0−8 h) (nM h) | 15,100 | 37,300 |
| C0 or Cmax (nM) | 13,400 | 9690 |
| C0 or Cmax unbound (nM) | 332 | 233 |
| Vdss (L/kg) | 0.42 | |
| CL (mL/min/kg) | 5.65 | |
| T1/2 (h) | 1.41 | 4.2 |
| F (%) | 34 |
| Compound | SPAA-52 | |
| dose route | 3 mg/kg PO | |
| AUC (0-12 h) (nM h) | 4660 | |
| Cmax (nM) | 877 | |
| Cmax unbound (nM) | 21 | |
| Vdss (L/kg) | 0.42 | |
| Tmax (h) | 2.0 | |
| T1/2 (h) | 2.4 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2837000-75-4
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Appearance Solid
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분자량 388.03
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화학식 C8H8Br2N2O4S
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Color White to off-white
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SMILES
O=S(O)(NC(NC1=CC(Br)=C(C)C(Br)=C1)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 100 mg/mL (257.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5771 mL | 12.8856 mL | 25.7712 mL | 64.4280 mL |
| 5 mM | 0.5154 mL | 2.5771 mL | 5.1542 mL | 12.8856 mL | |
| 10 mM | 0.2577 mL | 1.2886 mL | 2.5771 mL | 6.4428 mL | |
| 15 mM | 0.1718 mL | 0.8590 mL | 1.7181 mL | 4.2952 mL | |
| 20 mM | 0.1289 mL | 0.6443 mL | 1.2886 mL | 3.2214 mL | |
| 25 mM | 0.1031 mL | 0.5154 mL | 1.0308 mL | 2.5771 mL | |
| 30 mM | 0.0859 mL | 0.4295 mL | 0.8590 mL | 2.1476 mL | |
| 40 mM | 0.0644 mL | 0.3221 mL | 0.6443 mL | 1.6107 mL | |
| 50 mM | 0.0515 mL | 0.2577 mL | 0.5154 mL | 1.2886 mL | |
| 60 mM | 0.0430 mL | 0.2148 mL | 0.4295 mL | 1.0738 mL | |
| 80 mM | 0.0322 mL | 0.1611 mL | 0.3221 mL | 0.8054 mL | |
| 100 mM | 0.0258 mL | 0.1289 mL | 0.2577 mL | 0.6443 mL |
SPAA-52 Related Classifications
HY-151591 Related Classifications
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