Cat. No.: HY-W067716

Spinacine

(Synonyms: (S)-Spinacine)

고객리뷰

Based on 1 Customer Validation

Spinacine ((S)-Spinacine) is a GABA uptake inhibitor. Spinacine enhances synaptic GABA effects via inhibition of gamma-aminobutyric acid uptake in cerebral cortex slices. Spinacine inhibits reflex responses of ventral roots in isolated spinal cord. Spinacine inhibits motor activity and reduces approaches to water dispensers in conflict situations. Spinacine raises pain sensitivity threshold via subarachnoidal injection.

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Purity: 99.96%
CAS No.: 59981-63-4
화학식: C₇H₉N₃O₂
분자량:167.17

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Spinacine Chemical Structure

CAS No.: 59981-63-4

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Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Spinacine inhbits GABA uptake by rat cerebral cortex with an IC₅₀ of 30 μM^[1].
Spinacine (0.1 mM) inhibits the re-
flex responses of the ventral roots of the isolated spinal cord^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Spinacine (10 mg/kg; i.p.; single dose) reduces motor activity, decreasing horizontal movements and approaches to a water dispenser in a conflict situation test, while the number of drinkings of water unchanged in rats^[1].
Spinacine (3 mg/kg; subarachnoidal; single dose) increases rats' pain sensitivity threshold by 1.5-2-fold for 1 hour^[1].
Spinacine (100 mg/kg; i.p.; single dose) has no detectable effect on white mice motor activity, orientative behavior, corazole-induced convulsions, or muscle tone^[1].
Spinacine (100 mg/kg; i.p.; single dose) does not exhibit analgesic activity in mice tested via mechanical tail compression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Normal rat^[1]
Dosage:

10 mg/kg
Administration:

i.p.; single dose
Result:

Reduced mean horizontal movements to 35.7 ± 19.4 over 20 minutes.
Reduced mean approaches to water dispenser to 10.3 ± 4.4 over 20 minutes.
Left mean water takings unchanged at 6.8 ± 1.72 over 20 minutes.
Produced statistically significant changes in approaches and horizontal movement compared to controls.

Chemical Information

CAS No. 59981-63-4
Appearance Solid
분자량 167.17
화학식 C₇H₉N₃O₂
Color White to off-white
SMILES

O=C([C@@H]1CC2=C(NC=N2)CN1)O
Synonyms

(S)-Spinacine
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

H₂O : 33.33 mg/mL (199.38 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.9819 mL

29.9097 mL

59.8193 mL

5 mM

1.1964 mL

5.9819 mL

11.9639 mL

10 mM

0.5982 mL

2.9910 mL

5.9819 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 4.55 mg/mL (27.22 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Boreisha I K, et al. Spinacine—an inhibitor of γ-aminobutyric acid uptake[J]. Pharmaceutical Chemistry Journal, 1988, 22(1): 15-17.

[2]. Han Y N, et al. Spinacine from Panax ginseng[J]. Archives of Pharmacal Research, 1987, 10(4): 258-259.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	5.9819 mL	29.9097 mL	59.8193 mL	149.5484 mL
	5 mM	1.1964 mL	5.9819 mL	11.9639 mL	29.9097 mL
	10 mM	0.5982 mL	2.9910 mL	5.9819 mL	14.9548 mL
	15 mM	0.3988 mL	1.9940 mL	3.9880 mL	9.9699 mL
	20 mM	0.2991 mL	1.4955 mL	2.9910 mL	7.4774 mL
	25 mM	0.2393 mL	1.1964 mL	2.3928 mL	5.9819 mL
	30 mM	0.1994 mL	0.9970 mL	1.9940 mL	4.9849 mL
	40 mM	0.1495 mL	0.7477 mL	1.4955 mL	3.7387 mL
	50 mM	0.1196 mL	0.5982 mL	1.1964 mL	2.9910 mL
	60 mM	0.0997 mL	0.4985 mL	0.9970 mL	2.4925 mL
	80 mM	0.0748 mL	0.3739 mL	0.7477 mL	1.8694 mL
	100 mM	0.0598 mL	0.2991 mL	0.5982 mL	1.4955 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Spinacine

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

Natural Product Library

Peptidomimetic Library

Neurotransmitter Receptor Compound Library

Anti-Alzheimer's Disease Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

GABA Receptor Compound Library

Human Metabolite Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

3D Diverse Fragment Library

MCE Kinase Hinge Binder Fragment Library

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Spinacine

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

Natural Product Library

Peptidomimetic Library

Neurotransmitter Receptor Compound Library

Anti-Alzheimer's Disease Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

GABA Receptor Compound Library

Human Metabolite Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

3D Diverse Fragment Library

MCE Kinase Hinge Binder Fragment Library

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Spinacine Related Classifications

HY-W067716 Related Classifications