STING agonist-47
STING agonist-47 is a STING agonist with an EC50 of 0.72 μM and a Kd of 176 nM. STING agonist-47 is a dimer of MSA-2 (HY-136927). STING agonist-47 can be used for the research of cancer, such as breast cancer.
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- 화학식: C28H26O8S4
- 분자량:618.76
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
STING agonist-47 (Compound SC2S) (0.71 μM, 24 h) activates the interferon pathway in THP-1 Lucia ISG cells[1].
STING agonist-47 (5 μM, 0.5-4 h) treatment of THP-1 Lucia ISG cells leads to significantly increased phosphorylation levels of key STING pathway proteins (pSTING, pTBK1, pIRF3)[1].
STING agonist-47 (25 μM, 6 h) induces IFN-β secretion in THP-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
STING agonist-47 (8.6 mg/kg, intratumoral injection) inhibits tumor growth in BALB/c mice inoculated with CT26mβGUS colon cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:2-day-post-fertilization (dpf) casper or nacre mutant zebrafish xenografted with Hs578T triple-negative breast cancer cells[1]
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Dosage:0.62 μM
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Administration:Immersion administration, daily from 1 day post-infection to 4 for 3 consecutive days
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Result:Induced tumor cell apoptosis (activates Caspase3).
Reduced tumor size and increased the number of tumor-associated macrophages (TAM).
Promoted macrophage polarization to the proinflammatory M1 phenotype (expressing TNF).
Chemical Information
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분자량 618.76
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화학식 C28H26O8S4
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SMILES
COC1=CC2=C(C=C1SCCSC3=CC4=C(SC(C(CCC(O)=O)=O)=C4)C=C3OC)C=C(S2)C(CCC(O)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
STING agonist-47 Related Classifications
HY-178338 Related Classifications
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