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Cat. No.: HY-P12128

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SYN1753

SYN1753 is a selective inhibitor of human neonatal Fc receptor (hFcRn) with a K_d value of 0.5 μM. SYN1753 binds to the albumin-binding site of hFcRn, inhibits the hFcRn-albumin interaction, and thereby suppresses FcRn-mediated transcytosis of human albumin. SYN1753 can be used in studies related to acetaminophen-induced liver injury.

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화학식: C₉₉H₁₃₇N₂₇O₂₅S₂
분자량:2169.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SYN1753 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

hFcRn

0.5 μM (Kd)

In Vitro

SYN1753 is a specific peptide inhibitor of the human FcRn-albumin interaction that binds to the albumin-specific epitope on FcRn, with a K_d of 0.5 μM at pH 6.0^[1].
SYN1753 inhibits hFcRn-mediated albumin transcytosis in polarized MDCK II cells^[1].
SYN1753 (1 mM; 1 h) binds to a shared site on recombinant shFcRn/β2m molecules, forming a stable complex with intramolecular disulfide bonds and putative hydrogen bonds^[1].
SYN1753 inhibits the transcytosis of human albumin in both basolateral-to-apical and apical-to-basolateral directions in MDCK II cells co-expressing hFcRn and hβ2m^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

분자량 2169.44
화학식 C₉₉H₁₃₇N₂₇O₂₅S₂
SMILES

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H]([C@H](O)C)C(N)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CCCCN)C(N[C@@H](CC6=CNC=N6)C(NCC(N[C@H]3CC7=CNC8=CC=CC=C78)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
Sequence

Ac-Arg-Tyr-Phe-Cys-Thr-Lys-Trp-Lys-His-Gly-Trp-Cys-Glu-Glu-Val-Gly-Thr-NH2 (disulfide bridge:Cys4-Cys12)
Sequence Shortening

Ac-RYFCTKWKHGWCEEVGT-NH2 (disulfide bridge:Cys4-Cys12)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Pyzik M, et al. Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proceedings of the National Academy of Sciences of the United States of America. 2017 Apr 04;114(14):E2862-E2871. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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