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Cat. No.: HY-163366

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TRK-IN-28

TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC₅₀ values of 0.55 nM, 25.1 nM and 5.4 nM against TRK^WT, TRK^G595R and TRK^G667C, respectively. TRK-IN-2 shows antiproliferative activity with IC₅₀ values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKA^WT, Ba/F3-ETV6-TRKB^WT, Ba/F3-LMNA-TRK^G595R and Ba/F3-LMNA-TRKA^G667C, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2991504-43-7
화학식: C₂₇H₂₅F₂N₇
분자량:485.53

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

TRK-IN-28 Chemical Structure

CAS No.: 2991504-43-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
Protocol
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Trk Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	205 nM Compound: 30f	Antiproliferative activity against mouse BaF3 cells harbouring LMNA-TRKA G595R mutant assessed as cell viability measured after 72 hrs by CCK-8 method Antiproliferative activity against mouse BaF3 cells harbouring LMNA-TRKA G595R mutant assessed as cell viability measured after 72 hrs by CCK-8 method	[PMID: 38271867]
BaF3	IC₅₀	3.7 nM Compound: 30f	Antiproliferative activity against mouse BaF3 cells harbouring ETV6-TRKB wildtype assessed as cell viability measured after 72 hrs by CCK-8 method Antiproliferative activity against mouse BaF3 cells harbouring ETV6-TRKB wildtype assessed as cell viability measured after 72 hrs by CCK-8 method	[PMID: 38271867]
BaF3	IC₅₀	48.3 nM Compound: 30f	Antiproliferative activity against mouse BaF3 cells harbouring LMNA-TRKA G667C mutant assessed as cell viability measured after 72 hrs by CCK-8 method Antiproliferative activity against mouse BaF3 cells harbouring LMNA-TRKA G667C mutant assessed as cell viability measured after 72 hrs by CCK-8 method	[PMID: 38271867]
BaF3	IC₅₀	9.5 nM Compound: 30f	Antiproliferative activity against mouse BaF3 cells harbouring ETV6-TRKA wildtype assessed as cell viability measured after 72 hrs by CCK-8 method Antiproliferative activity against mouse BaF3 cells harbouring ETV6-TRKA wildtype assessed as cell viability measured after 72 hrs by CCK-8 method	[PMID: 38271867]

Chemical Information

CAS No. 2991504-43-7
분자량 485.53
화학식 C₂₇H₂₅F₂N₇
SMILES

FC1=CC(CC2=CC3=C(NN=C3NC4=C5C=CC(N6CCN(CC6)C)=CC5=NC=N4)C=C2)=CC(F)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

Cell Assay

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Xu Y, et al. Design, synthesis and evaluate of indazolylaminoquinazoline derivatives as potent Tropomyosin receptor kinase (TRK) inhibitors. Bioorg Med Chem. 2024;99:117608. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
Protocol
순도&문서
References

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TRK-IN-28

All Trk Receptor Isoforms