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Cat. No.: HY-N19031

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Vernolepin

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 18542-37-5
화학식: C₁₅H₁₆O₅
분자량:276.29

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Vernolepin Chemical Structure

CAS No.: 18542-37-5

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	16.9 μM Compound: 5	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by WST-8 assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by WST-8 assay	[PMID: 27311895]
HeLa	IC₅₀	2.2 μM Compound: 5	Antiproliferation activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by WST-8 assay Antiproliferation activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by WST-8 assay	[PMID: 27311895]
MDA-MB-231	IC₅₀	1.9 μM Compound: 5	Antiproliferation activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by WST-8 assay Antiproliferation activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by WST-8 assay	[PMID: 27311895]

In Vitro

Cell Cytotoxicity Assay^[1]

View Protocol

Cell Line:

A549, HeLa, HuCCA-1, HepG2, H69AR, T47-D, MDA-MB-231, S102, HL-60, MOLT-3, MRC-5
Concentration:

0.016-50 μg/mL
Incubation Time:

48 h
Result:

Exhibited cytotoxic activity across all tested cancer cell lines with the following IC₅₀ values: 13.73 μM (A549), 11.27 μM (HeLa), 9.31 μM (HuCCA-1), 20.15 μM (HepG2), 8.70 μM (H69AR), 9.31 μM (T47-D), 19.35 μM (MDA-MB-231), 30.58 μM (S102), 3.84 μM (HL-60), 5.29 μM (MOLT-3).
Showed selective cytotoxicity with selectivity indices ≥3.0 across all cancer cell lines, with an IC₅₀ of 91.49 μM against normal MRC-5 cells.

Apoptosis Analysis^[1]

View Protocol

Cell Line:

HepG2
Concentration:

10 μM
Incubation Time:

48 h
Result:

Induced morphological changes and cell detachment in HepG2 cells.
Increased total apoptotic cell populations to 20.0%, compared to a basal apoptosis level of 6.7% in untreated control cells.

Cell Cycle Analysis^[1]

View Protocol

Cell Line:

HepG2
Concentration:

10 μM
Incubation Time:

48 h
Result:

Decreased the proportion of cells in G0/G1 (40.4%) and S (8.0%) phases.
Increased the proportion of cells in G2/M phase to 51.5%, compared to control cells with 49.8% in G0/G1, 11.6% in S, and 38.4% in G2/M.

Chemical Information

CAS No. 18542-37-5
분자량 276.29
화학식 C₁₅H₁₆O₅
SMILES

C(=C)[C@@]12[C@@]([C@@]3([C@@]([C@@H](O)C1)(C(=C)C(=O)O3)[H])[H])(C(=C)C(=O)OC2)[H]
Structure Classification
- Terpenoids
- Sesquiterpenes
- Terpenoids
- Diterpenoids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Thongnest S, et al. Vernodalidimer L, a sesquiterpene lactone dimer from Vernonia extensa and anti-tumor effects of vernodalin, vernolepin, and vernolide on HepG2 liver cancer cells. Bioorganic chemistry. 2019 Nov;92:103197. [Content Brief]

[2]. Kupchan S M, et al. Tumor inhibitors. XLVI. Vernolepin, a novel sesquiterpene dilactone tumor inhibitor from Vernonia hymenolepis[J]. The Journal of Organic Chemistry, 1969, 34(12): 3903-3908.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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CAS No.:
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Purity:
수량:

Vernolepin

Biological Activity

Cellular Effect

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Vernolepin Related Classifications

HY-N19031 Related Classifications

Bioz

Keywords

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