VU534
Based on 1 Customer Validation
VU534 is a NAPE-PLD activator, with an EC50 of 0.30 μM. VU534 is dual inhibitors of FAAH and sEH (IC50 of 1.2 μM). VU534 increases efferocytosis in a NAPE-PLD dependent manner. VU534 has the potential for cardiometabolic diseases study [1] .
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.10%
- CAS No.: 923509-20-0
- 화학식: C21H22FN3O3S2
- 분자량:447.55
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Anti-Infection Compound Library
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Metabolism/Protease Compound Library
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Neuronal Signaling Compound Library
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Anti-Cardiovascular Disease Compound Library
HY-L046
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Lipid Metabolism Compound Library
HY-L091
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Pain-Related Compound Library
HY-L139
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Metabolic Enzyme Compound Library
HY-L146
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
NAPE-PLD activator, with an EC50 of 0.30 μM
VU534 (up to 30 μM, 24 h) shows minimal cytotoxicity in HepG2 and Raw264.7 cell lines [1].
VU534 (3-30 μM, 1 h) increases NAPE-PLD activity in Raw264.7 cells [1].
VU534 (1 h) increases NAPE-PLD activity in HepG2 cells, with the EC50 values of 1.5 μM[1].
VU534 (5 μM, 1 h) increases NAPE-PLD activity 1.5-fold, but not reverses LEI-401(HY-131181)-inhibited NAPE-PLD activity [1].
VU534 (10 μM, 6 h) significantly enhances efferocytosis in bone-marrow-derived macrophages, but not work in Napepld-/- KO[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 923509-20-0
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Appearance Solid
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분자량 447.55
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화학식 C21H22FN3O3S2
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Color White to off-white
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SMILES
CC1=CC(C)=C2SC(NC(C3CCN(S(=O)(C4=CC=C(C=C4)F)=O)CC3)=O)=NC2=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 25 mg/mL (55.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2344 mL | 11.1719 mL | 22.3439 mL | 55.8597 mL |
| 5 mM | 0.4469 mL | 2.2344 mL | 4.4688 mL | 11.1719 mL | |
| 10 mM | 0.2234 mL | 1.1172 mL | 2.2344 mL | 5.5860 mL | |
| 15 mM | 0.1490 mL | 0.7448 mL | 1.4896 mL | 3.7240 mL | |
| 20 mM | 0.1117 mL | 0.5586 mL | 1.1172 mL | 2.7930 mL | |
| 25 mM | 0.0894 mL | 0.4469 mL | 0.8938 mL | 2.2344 mL | |
| 30 mM | 0.0745 mL | 0.3724 mL | 0.7448 mL | 1.8620 mL | |
| 40 mM | 0.0559 mL | 0.2793 mL | 0.5586 mL | 1.3965 mL | |
| 50 mM | 0.0447 mL | 0.2234 mL | 0.4469 mL | 1.1172 mL |
VU534 Related Classifications
HY-155773 Related Classifications
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