Z-Pro-prolinal
Based on 1 Customer Validation
Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.9%
- CAS No.: 88795-32-8
- 화학식: C18H22N2O4
- 분자량:330.38
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
IC50: 0.4 nM (porcine PREP)[2]
Ki: 3.7 nM (PREP from bovine brain)[1]
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats[3]
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Dosage:100 mg/kg
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Administration:Oral administration, once
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Result:Significantly increased the septal arginine-vasopressin (AVP) content.
Chemical Information
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CAS No. 88795-32-8
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Appearance Solid
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분자량 330.38
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화학식 C18H22N2O4
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Color White to off-white
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SMILES
O=C[C@H]1N(C([C@H]2N(C(OCC3=CC=CC=C3)=O)CCC2)=O)CCC1
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Synonyms
N-Benzyloxycarbonyl-L-prolyl-L-prolinal
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Tsuru D, et al. Thiazolidine derivatives as potent inhibitors specific for prolyl endopeptidase. J Biochem. 1988;104(4):580-586. [Content Brief]
[2]. Kilpeläinen TP, et al. The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy. Biomed Pharmacother. 2020;128:110253. [Content Brief]
[3]. Miura N, et al. Increase in the septal vasopressin content by prolyl endopeptidase inhibitors in rats. Neurosci Lett. 1995;196(1-2):128-130. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Z-Pro-prolinal Related Classifications
HY-134454A Related Classifications
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