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Cat. No.: HY-155053

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ZIKV-IN-6

ZIKV-IN-6 (compound 22) is an inhibitor of Zika virus (ZIKV), with low cytotoxicity (CC₅₀＞50 μM). ZIKV-IN-6 binds to ZIKV RdRp directly and inhibits viral RNA synthesis by ZIKV NS5. ZIKV-IN-6 suppresses the excessive inflammatory response and pyroptosis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₇H₂₉NO₆
분자량:463.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

ZIKV-IN-6 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Zika virus (ZIKV)^[1]

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>50 μM Compound: 22	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37421888]
JEG-3	CC₅₀	54.7 μM Compound: 22	Cytotoxicity against human JEG-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human JEG-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37421888]
SNB-19	CC₅₀	66.1 μM Compound: 22	Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37421888]
Vero	CC₅₀	65.4 μM Compound: 22	Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37421888]

Chemical Information

분자량 463.52
화학식 C₂₇H₂₉NO₆
SMILES

O=C1C2=C(C(O)=C(N3CCC(C4=CC=CC=C4)CC3)C=C2O)C(C5=C1C[C@@](C)(O)[C@@](C)(O)C5)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhu Y, et al. Design, synthesis, and biological evaluation of a series of new anthraquinone derivatives as anti-ZIKV agents. Eur J Med Chem. 2023 Oct 5;258:115620. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

ZIKV-IN-6

All DNA/RNA Synthesis Isoforms

Biological Activity

제품 설명

IC50 & Target

Cellular Effect

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ZIKV-IN-6 Related Classifications

HY-155053 Related Classifications

Bioz

Keywords

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