2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS inhibitor-15

KRAS inhibitor-15 (compound 3-19) is a potent KRAS G12C inhibitor with an IC50 of 0.954 µM. KRAS inhibitor-15 shows p-ERK inhibition activities with IC50s of 2.03, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-15 has the potential for the research of pancreatic, colorectal, and lung cancers.

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KRAS inhibitor-15

KRAS inhibitor-15 Chemical Structure

CAS No. : 2230873-75-1

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KRAS inhibitor-15 Related Antibodies

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Description

KRAS inhibitor-15 (compound 3-19) is a potent KRAS G12C inhibitor with an IC50 of 0.954 µM. KRAS inhibitor-15 shows p-ERK inhibition activities with IC50s of 2.03, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-15 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

IC50 & Target[1]

KRas G12C

0.954 μM (IC50)

Masse moléculaire

451.34

Formule

C20H17Cl2FN4OS
CAS No.
SMILES

C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(N)=CC=C4Cl)=C(C3=NS2)F)Cl)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

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Pureté et documentation
Références
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KRAS inhibitor-15 Related Classifications

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Keywords:

KRAS inhibitor-152230873-75-1KRAS inhibitor15KRAS inhibitor 15RasMIA PaCA-2A549anticancerp-ERKpancreaticcolorectallung cancerInhibitorinhibitorinhibit

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