L-2-Phosphoglyceric acid sodium hydrate
Based on 1 Customer Validation
L-2-Phosphoglyceric acid sodium hydrate is an endogenous metabolite. L-2-Phosphoglyceric acid sodium hydrate serves as a substrate for phosphatases and releases inorganic phosphate upon catalytic dephosphorylation. L-2-Phosphoglyceric acid sodium hydrate is upregulated in human oral fibroblasts treated with Porphyromonas gingivalis bacterial extracellular vesicles. L-2-Phosphoglyceric acid sodium hydrate is useful for research related to prostate cancer and periodontitis.
For research use only. We do not sell to patients.
- Purity : 89.70%
- Formula: C3H7Na2O8P
- Molecular Weight:248.04
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
L-2-Phosphoglyceric acid sodium hydrate levels in PC3 prostate cancer cells decrease upon treatment with a glutaminase inhibitor and increase upon treatment with the hexokinase inhibitor 2-deoxy-D-glucose (HY-13966), reflecting the metabolic crosstalk between glycolysis and glutaminolysis pathways[2].
L-2-Phosphoglyceric acid sodium hydrate is catalyzed by wild-type Gph and its evolved/single-mutant variants with significant phosphoglycolate phosphatase activity, indicating that the native activity of the enzyme remains largely intact after directed evolution toward phosphoserine phosphatase activity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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Appearance Solid
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Molecular Weight 248.04
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Formula C3H7Na2O8P
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Color White to off-white
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SMILES
O=C(O[Na])[C@@H](OP(O)(O[Na])=O)CO.O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (403.16 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. SUTHERLAND EW, et al. Mechanism of the phosphoglyceric mutase reaction. J Biol Chem. 1949 Nov;181(1):153-9. [Content Brief]
[2]. Dong XM, et al. Targeted profiling of polar metabolites in cancer metabolic reprogramming by hydrophilic interaction liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2022 Dec 20;1686:463654. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.0316 mL | 20.1580 mL | 40.3161 mL | 100.7902 mL |
| 5 mM | 0.8063 mL | 4.0316 mL | 8.0632 mL | 20.1580 mL | |
| 10 mM | 0.4032 mL | 2.0158 mL | 4.0316 mL | 10.0790 mL | |
| 15 mM | 0.2688 mL | 1.3439 mL | 2.6877 mL | 6.7193 mL | |
| 20 mM | 0.2016 mL | 1.0079 mL | 2.0158 mL | 5.0395 mL | |
| 25 mM | 0.1613 mL | 0.8063 mL | 1.6126 mL | 4.0316 mL | |
| 30 mM | 0.1344 mL | 0.6719 mL | 1.3439 mL | 3.3597 mL | |
| 40 mM | 0.1008 mL | 0.5040 mL | 1.0079 mL | 2.5198 mL | |
| 50 mM | 0.0806 mL | 0.4032 mL | 0.8063 mL | 2.0158 mL | |
| 60 mM | 0.0672 mL | 0.3360 mL | 0.6719 mL | 1.6798 mL | |
| 80 mM | 0.0504 mL | 0.2520 mL | 0.5040 mL | 1.2599 mL | |
| 100 mM | 0.0403 mL | 0.2016 mL | 0.4032 mL | 1.0079 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-2-Phosphoglyceric acid sodium hydrate Related Classifications
HY-128736C Related Classifications
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Keywords
- L-2-Phosphoglyceric acid sodium
- Endogenous Metabolite
- phosphoglyceric acid isomer
- phosphatase substrate
- phosphorylated glycolytic intermediate metabolite
- prostate cancer cells
- PC3 prostate cancer cells
- phosphoglycerate mutase
- D-2-phosphoglyceric acid
- Porphyromonas gingivalis extracellular vesicles
- Gph
- human oral fibroblasts
- Inhibitor
- inhibitor
- inhibit