1. Metabolic Enzyme/Protease
  2. Herbicide Glutaminase
  3. L-Phosphinothricin

L-Phosphinothricin is a glutamine synthetase inhibitor and a non-selective herbicide. L-Phosphinothricin acts as a competitive inhibitor, induces toxic ammonium ion accumulation in plants and bacteria, and indirectly blocks the photosynthesis process. L-Phosphinothricin exerts herbicidal activity against both monocotyledonous and dicotyledonous plant species, is primarily absorbed through plant leaves, exhibits limited translocation in plants, and undergoes rapid degradation by soil microorganisms with no root uptake. L-Phosphinothricin can be used for research on weed control in agricultural and non-crop scenarios.

For research use only. We do not sell to patients.

L-Phosphinothricin

L-Phosphinothricin Chemical Structure

CAS No. : 35597-44-5

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Description

L-Phosphinothricin is a glutamine synthetase inhibitor and a non-selective herbicide. L-Phosphinothricin acts as a competitive inhibitor, induces toxic ammonium ion accumulation in plants and bacteria, and indirectly blocks the photosynthesis process. L-Phosphinothricin exerts herbicidal activity against both monocotyledonous and dicotyledonous plant species, is primarily absorbed through plant leaves, exhibits limited translocation in plants, and undergoes rapid degradation by soil microorganisms with no root uptake. L-Phosphinothricin can be used for research on weed control in agricultural and non-crop scenarios[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
>500 μM
Compound: 3, PT
Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate production
Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate production
[PMID: 17722902]
HEK293 EC50
1100 μM
Compound: 3, PT
Agonist activity at rat mGluR4 receptor expressed HEK293 cells assessed as effect on inositol phosphate production
Agonist activity at rat mGluR4 receptor expressed HEK293 cells assessed as effect on inositol phosphate production
[PMID: 17722902]
HEK293 EC50
412 μM
Compound: 3, PT
Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effect on inositol phosphate production
Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effect on inositol phosphate production
[PMID: 17722902]
In Vivo

L-Phosphinothricin (150 g a.i./ha; single post-emergence foliar spray) exhibits time-declining control efficacy against Eleusine indica, with a maximum efficacy of 40% at 7 days after application (DAA) and a reduced efficacy of 10% at 28 DAA[1].
L-Phosphinothricin (150 g a.i./ha; single post-emergence foliar spray) exerts sustained high control against Brachiaria decumbens with 75% efficacy at 7 DAA and 85% efficacy from 14 to 21 DAA, delivers stable high control of Euphorbia heterophylla with a minimum efficacy of 88.8% across 7 to 28 DAA, and achieves potent control of Borreria verticilata with 90% efficacy at 7 DAA and 80% efficacy at 14 DAA[1].
L-Phosphinothricin (150 g a.i./ha; foliar spray; single application) applied post-emergence provides minimal control of Lolium species[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

181.13

Formula

C5H12NO4P

CAS No.
SMILES

C([C@@H](C(O)=O)N)CP(C)(=O)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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L-Phosphinothricin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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L-Phosphinothricin
Cat. No.:
HY-160735
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