Conjugatable Lipids

DSPE-PEG1000-SH is an amphiphilic poly-PEG that can form lipid bilayers in water. This amphiphilic polymer can form lipid bilayers in aqueous solution and can be used to embed active molecules for drug delivery systems such as mRNA vaccines.

Oleic-DBCO is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Oleic-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

DSPE-PEG5000-azide is a click chemistry reactive phospholipid polyPEG which forms lipid bilayer or micelles in an aqueous solution. The polymer can be used to prepare liposomes or nanoparticles used for delivering nutrients or therapeutic agents, for example mRNA or DNA vaccine.

DSPE-PEG2-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

16:0 Succinyl PE is a carboxylic acid-functionalized lipid with a two carbon linker to a phosphoethanolamine bound to two palmitic acid tails.

DSPE-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DSPE-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

DSPE-PEG2000-amine sodium is a pegylated derivative of 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (HY-112530), which can be used to synthesize solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.

DSPE-PEG3400-Biotin is a phospholipid PEG for biotinylation. The amphiphilic property of the DSPE-PEG is useful for precision drug delivery and cancer therapy.

DSPE-PEG2000-Azide ammonium is an azide-functionalized phospholipid and lipid-polyethylene glycol conjugate. DSPE-PEG2000-Azide ammonium serves as a component of azide-functionalized liposome nanoparticles, which enables conjugation with DBCO-modified antibodies and proteins via strain-promoted alkyne-azide cycloaddition, and can also passively insert into exosome membranes through hydrophobic interactions, thereby achieving modular surface engineering via azide-alkyne click chemistry. DSPE-PEG-Azide ammonium binds to bovine milk exosomes with a K_D of 347 μM.

DSPE-PEG1000-NHS is a PEG-modified phospholipid derivative that can be used to prepare liposomes. DSPE-PEG1000-NHS is commonly employed as a linker molecule for the surface modification of liposomes to confer targeting capabilities. DSPE-PEG1000-NHS can be used in the study of drug delivery.

DSPE-PEG3400-azide is a polydisperse PEG covalently attached to a phospholipid. The polymer is an amphiphilic molecule with hydrophobic fatty acid chains and hydrophilic PEG head which enables lipid bilayer or micelles formation in water. The phospholipid PEG can be used to prepare liposome or nanoparticles for targeted drug delivery and is reactive with alkyne to form triazole bond.

DSPE-PEG6-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

16:0 Biotinyl PE is a biotin-functionalized lipid attached to a phosphoethanolamine linked to two palmitic acid groups.

Photoclick sphingosine (Pacsph) is a photosensitizing and clickable sphingosine analog. Photoclick sphingosine is metabolized in cells into endogenous lipid metabolic pathways and can be visualized by its clickable alkyne group. Photoclick sphingosine can be used to study intracellular sphingolipid metabolism and subcellular localization.

DSPE-PEG3-azide (DSPE-PEG3-N3) is an azide containing lipid that can be used to form micelles as nanoparticles for drug delivery. DSPE-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

DSPE-PEG2000-endo-BCN is a PEG-lipid conjugate and distearyl phosphatidylethanolamine-polyethylene glycol (DSPE-PEG) derivative. DSPE-PEG2000-endo-BCN improves the delivery efficiency and tissue specificity of poorly soluble drugs and can be used in drug delivery research.

Cholesterol-PEG1000-acid is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-acid can be used in drug delivery research.

DSPE-PEG20000-NHS ammonium is one of the most commonly used reactive phospholipids for coupling antibodies, proteins, peptides or other substrates to the surface of liposomes and other lipid PEG nanoparticles.

DOPE-PEG3400-Mal is a phospholipid. Phospholipids have good biocompatibility and significant amphiphilic characteristics, making them the main and suitable dosage form or excipient in drug formulations, thereby achieving better therapeutic effects. DOPE-PEG3400-Malcan be used in drug delivery research.

Stearic acid-PEG5000-Mal enables surface modification of various substrate through reaction between hydroxyl and ethoxyl silane. The polymer can be used for click chemistry with alkyne containing molecule.