2. Cell Cycle/DNA Damage
  3. CDK
  4. LQ23

LQ23 is a selective inhibitor for CDC2-like kinase 2 (CLK2) with an IC50 of 1.4 nM. LQ23 exhibits anti-inflammatory activity.

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LQ23

LQ23 Estructura química

No. CAS : 2997615-62-8

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LQ23 Related Antibodies

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Descripciòn

LQ23 is a selective inhibitor for CDC2-like kinase 2 (CLK2) with an IC50 of 1.4 nM. LQ23 exhibits anti-inflammatory activity[1].

IC50 & Target

IC50: 1.4 nM (CLK2), 2.1 nM (CLK1), 3.2 nM (CLK4), 21.7 nM (DYRK1A), >100 nM (CLK3)
In Vitro

LQ23 (10-100 nM) dose-dependently inhibits SR protein phosphorylation in chondrocytes, and thereby regulates the selective cleavage of genes[1].
LQ23 (10-100 nM) dose-dependently inhibits CHIR99021-stimulated Wnt-signaling in HEK-293T cells with IC50 of 2.9 μM[1].
LQ23 (30 nM) ameliorates osteoarthritis through promotes the bone mesenchymal stem cells (BMSC) differentation into chondrocytes and suppresses the cartilage degradation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LQ23 Related Antibodies

Western Blot Analysis[1]

Cell Line: Chondrocytes
Concentration: 10-100 nM
Incubation Time: 1 h
Result: Reduced phosphorylated SRSF4, SRSF5 and SRSF6.
Reduced levels of β-catenin and c myc.
In Vivo

LQ23 (1.5 μg/ kg, single IA injection) inhibits inflammation, protects cartilage and improves function in the monosodium iodoacetate (MIA)-induced and ACLT-pMMx-induced osteoarthritis in Sprague-Dawley rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MIA-/ACLT-pMMx-induced osteoarthritis in Sprague-Dawley rats model[1]
Dosage: 1.5 μg/ kg
Administration: Single IA injection
Result: Ameliorated the surface of the articular cartilage and the cell arrangement, reduced the thickness of the synovium, increased the gap between the femur and the tibia.
Reduced the levels of inflammatory cytokines and catabolic enzymes.
Peso molecular

416.54

Fòrmula

C24H24N4OS
No. CAS
SMILES

N[C@H](COC1=CC(C2=CC=C(C3=C2)NN=C3C#CC4=CSC=C4)=CN=C1)CC(C)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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Referencias
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LQ23 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LQ232997615-62-8LQ 23LQ-23CDKCyclin dependent kinaseosteoarthritisSprague Dawley ratsInhibitorinhibitorinhibit

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Nombre del producto:
LQ23
Cat. No.:
HY-162398
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