2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. LUF7244

LUF7244 is a selective allosteric modulator of Kv11.1 channels. LUF7244 inhibits early afterdepolarizations. LUF7244 can be used for anti-arrhythmia research.

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LUF7244 Chemical Structure

LUF7244 Chemical Structure

CAS No. : 1821638-43-0

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Based on 1 publication(s) in Google Scholar

LUF7244 Related Antibodies

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Description

LUF7244 is a selective allosteric modulator of Kv11.1 channels. LUF7244 inhibits early afterdepolarizations. LUF7244 can be used for anti-arrhythmia research[1].

In Vitro

LUF7244 (0-10 μM; HEK293 cells) binds Kv11.1 channels and increases IKv11.1 by inhibiting inactivation in a dose-dependent manner[1].
LUF7244 (0-10 μM; cardiomyocytes) reduces action potential duration (APD) by approximately 50% and dofetilide-induced early afterdepolarization (EAD) in isolated ventricular CMCs from SR and CAVB dogs[1].
LUF7244 (10 μM) had no effects on IKIR2.1, INav1.5, ICa-L, and IKs but doubled IKr[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LUF7244 Related Antibodies
In Vivo

LUF7244 (2.5 mg/kg; i.v.; for 15 min) decreases repolarization parameters. LUF7244 has antiarrhythmic effects against dofetilide-induced TdP arrhythmias in CAVB dogs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

366.80

Formula

C20H15ClN2O3
CAS No.
SMILES

O=C(NC1=CC=CN=C1)COC2=CC=C(C(C3=CC=CC(Cl)=C3)=O)C=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LUF7244 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LUF72441821638-43-0LUF 7244LUF-7244Potassium ChannelKcsAKv11.1early afterdepolarizationsanti-arrhythmiaaction potential durationcardiomyocytesInhibitorinhibitorinhibit

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