2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK)
  4. M4K2149

M4K2149 is a selective ALK2 inhibitor with an IC50 value of 17 nM. M4K2149 is applicable to research related to diffuse intrinsic pontine glioma.

For research use only. We do not sell to patients.

M4K2149

M4K2149 Chemical Structure

CAS No. : 2421140-72-7

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M4K2149 Related Antibodies

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Description

M4K2149 is a selective ALK2 inhibitor with an IC50 value of 17 nM. M4K2149 is applicable to research related to diffuse intrinsic pontine glioma[1].

IC50 & Target[1]

ALK2

17 nM (IC50)

In Vitro

M4K2149 potently inhibits WT ALK2 with an IC50 of 17 nM, shows comparable potency against DIPG-linked ALK2 mutants (G328V, R206H, R258G), and exhibits 34-fold selectivity for ALK2 over ALK5 in a radioactive in vitro biochemical kinase assay[1].
M4K2149 inhibits ALK2 binding in HEK293 cells with an IC50 of 55 nM in a NanoBRET assay and exhibits 13-fold cell-based selectivity for ALK2 over ALK5[1].
M4K2149 has reduced off-target activity against the hERG potassium channel in HEK293 cells, with an IC50 of >50 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

M4K2149 Related Antibodies
Molecular Weight

402.50

Formula

C24H26N4O2
CAS No.
SMILES

O=C(N)C1=CC=C(C=C1OC)C2=CN=CC(C3=CC=C(C=C3)N4CCNCC4)=C2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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M4K2149 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M4K21492421140-72-7Anaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246hERG potassium channelALK5D293G289ALK2 hinge region H286K235ALK2 serine/threonine kinaseV214HEK293 cellsdiffuse intrinsic pontine gliomaInhibitorinhibitorinhibit

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