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Cat. No.: HY-189476

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MCT4-IN-2

MCT4-IN-2 is an orally active monocarboxylate transporter MCT4 inhibitor. MCT4-IN-2 inhibits the activity of MCT4. MCT4-IN-2 can be used for the research of inflammatory diseases, proliferative diseases and pulmonary fibrosis.

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CAS No.: 2230187-60-5
Formule: C₂₇H₃₁N₃O₄
Masse moléculaire:461.55

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (285 KB)

MCT4-IN-2 Chemical Structure

CAS No.: 2230187-60-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

MCT4

Voir tous les produits spécifiques à Isoform Monocarboxylate Transporter :

In Vitro

MCT4-IN-2 (Compound 1) exhibits low inhibitory activity against hERG channels, with an IC₅₀ > 300 μM^[1].
MCT4-IN-2 attenuates the transformation of fibroblasts into myofibroblasts and reduces the production of the extracellular matrix protein α-smooth muscle actin (αSMA)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MCT4-IN-2 (Compound 1) (3 mg/kg; p.o.; twice daily) effectively reduces pulmonary fibrosis in vivo (effective in both young and aged mice); no significant synergistic effect is observed when it is used in combination with Pirfenidone (HY-B0673) or Nintedanib (HY-50904)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Pulmonary fibrosis mice^[1]
Dosage:

3 mg/kg
Administration:

p.o.; twice daily
Result:

Effectively reduced pulmonary fibrosis in vivo (in both young and aged mice).
There was no significant additive effect when used in combination with Pirfenidone or Nintedanib.

Related Protocols :

Chemical Information

CAS No. 2230187-60-5
Masse moléculaire 461.55
Formule C₂₇H₃₁N₃O₄
SMILES

O=C(C(C)(C)OCC1=NN(C(C2=CC(OC3CCC3)=CC=C2)=C1)C4=C(N5CCC5)C=CC=C4)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (285 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. PARNELL M, et al. International Application Published Under the Patent Cooperation Treaty (PCT): WO 2024/036243 A2. VETTORE, LLC; 2024 Feb 15.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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