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Cat. No.: HY-189476

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MCT4-IN-2

MCT4-IN-2 is an orally active monocarboxylate transporter MCT4 inhibitor. MCT4-IN-2 inhibits the activity of MCT4. MCT4-IN-2 can be used for the research of inflammatory diseases, proliferative diseases and pulmonary fibrosis.

For research use only. We do not sell to patients.

CAS No.: 2230187-60-5
Formula: C₂₇H₃₁N₃O₄
Molecular Weight:461.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MCT4-IN-2 Chemical Structure

CAS No.: 2230187-60-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

MCT4

All Monocarboxylate Transporter Isoforms :

In Vitro

MCT4-IN-2 (Compound 1) exhibits low inhibitory activity against hERG channels, with an IC₅₀ > 300 μM^[1].
MCT4-IN-2 attenuates the transformation of fibroblasts into myofibroblasts and reduces the production of the extracellular matrix protein α-smooth muscle actin (αSMA)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MCT4-IN-2 (Compound 1) (3 mg/kg; p.o.; twice daily) effectively reduces pulmonary fibrosis in vivo (effective in both young and aged mice); no significant synergistic effect is observed when it is used in combination with Pirfenidone (HY-B0673) or Nintedanib (HY-50904)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Pulmonary fibrosis mice^[1]
Dosage:

3 mg/kg
Administration:

p.o.; twice daily
Result:

Effectively reduced pulmonary fibrosis in vivo (in both young and aged mice).
There was no significant additive effect when used in combination with Pirfenidone or Nintedanib.

Chemical Information

CAS No. 2230187-60-5
Molecular Weight 461.55
Formula C₂₇H₃₁N₃O₄
SMILES

O=C(C(C)(C)OCC1=NN(C(C2=CC(OC3CCC3)=CC=C2)=C1)C4=C(N5CCC5)C=CC=C4)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. PARNELL M, et al. International Application Published Under the Patent Cooperation Treaty (PCT): WO 2024/036243 A2. VETTORE, LLC; 2024 Feb 15.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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