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  4. MD-B

MD-B is a •OH Fluorescent probe with blood-brain barrier permeability. MD-B undergoes single-electron oxidation by hydroxyl radicals (•OH), which triggers fluorescence enhancement and enables in-situ imaging of •OH. MD-B allows imaging analysis of hydroxyl radicals (•OH) in the mouse brain, revealing a positive correlation between elevated •OH levels and the severity of depressive phenotypes. MD-B can be used in depression-related research.

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MD-B

MD-B Chemical Structure

CAS No. : 2361037-36-5

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Description

MD-B is a •OH Fluorescent probe with blood-brain barrier permeability. MD-B undergoes single-electron oxidation by hydroxyl radicals (•OH), which triggers fluorescence enhancement and enables in-situ imaging of •OH. MD-B allows imaging analysis of hydroxyl radicals (•OH) in the mouse brain, revealing a positive correlation between elevated •OH levels and the severity of depressive phenotypes. MD-B can be used in depression-related research[1].

Molecular Weight

310.23

Formula

C14H9F3N2O3
CAS No.
SMILES

CC1=NN(C(C1)=O)C2=CC=C3C(OC(C=C3C(F)(F)F)=O)=C2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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MD-B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MD-B2361037-36-5Fluorescent Dyerestraint stressblood-brain barrierRAW 264.7 mouse macrophagesCUMS-susceptible micedepression phenotypehydroxyl radical (?OH)human astrocytesPC12 cellsdepression-like behaviormouse brainInhibitorinhibitorinhibit

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