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Art. -Nr.: HY-187058

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MDL-104168

MDL-104168 is a macrocyclic peptide mimetic HIV protease inhibitor (human IC₅₀: 2 nM; K_i: 20 nM). MDL-104168 can be used for the research of human immunodeficiency virus infection.

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CAS. Nr.: 158268-42-9
Formel: C₂₇H₃₀F₂N₄O₆
Molecular Weight:544.56

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

MDL-104168 Chemical Structure

CAS. Nr.: 158268-42-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

MDL-104168 is a macrocyclic peptide mimetic HIV protease inhibitor (human IC₅₀: 2 nM; K_i: 20 nM). MDL-104168 can be used for the research of human immunodeficiency virus infection^[1]^[2].

In Vitro

Viral InfectionOthers

Viral Infection

MDL-104168 (compound 69), a macrocyclic HIV protease inhibitor with a difluorostatone mimetic, inhibits purified HIV protease with a K_i of 20 nM and exhibits cell-based antiviral activity with an IC₅₀ of 2 nM^[1].
MDL-104168 (compound 8) (1 h) inhibits recombinant HIV-1 protease with a K_i of 20 nM^[2].

Others

MDL-104168 contains a difluorostatone moiety that achieves binding by situating fluorine atoms at hydrogen-bonding distances from the carboxylates of catalytic aspartyl residues, mimicking the key intermediate arising during the rate-limiting stage of substrate hydrolysis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

Chemical Information

CAS. Nr. 158268-42-9
Molecular Weight 544.56
Formel C₂₇H₃₀F₂N₄O₆
SMILES

C(C(C(NCC1=CC=CC=C1)=O)(F)F)(=O)[C@@H]2CC=3C=CC(=CC3)OCC(=O)NCC(=O)N[C@@H]([C@@H](C)C)C(=O)N2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Neshat Rozatian, et al. Fluorine-containing macrocyclic peptides and peptidomimetics. Org. Chem. Front. 2025; 12 (17): 4871–4895.

[2]. Podlogar BL, et al. Design, synthesis, and conformational analysis of a novel macrocyclic HIV-protease inhibitor. Journal of medicinal chemistry. 1994 Oct 28;37(22):3684-92. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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