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Cat. No.: HY-187426

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MDOLL-0591

MDOLL-0591 is a selective CHIKV nsP3 macrodomain inhibitor and antiviral agent, with an IC₅₀ of 10 μM against CHIKV nsP3. MDOLL-0591 inhibits the replication of CHIKV in cell culture systems. MDOLL-0591 is applicable to research related to Chikungunya virus infection.

For research use only. We do not sell to patients.

Formula: C₂₀H₁₇N₃O₃S
Molecular Weight:379.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MDOLL-0591 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	EC50	0.5 μM	Inhibition of CHIKV replication in human embryonic kidney HEK-293T cells assessed via NanoLuc luciferase activity at 20 hours post-infection with CHIKV-nLuc at MOI 0.05, with parallel ATP-based cell viability measurements confirming no significant cytotoxicity at tested concentrations. Inhibition of CHIKV replication in human embryonic kidney HEK-293T cells assessed via NanoLuc luciferase activity at 20 hours post-infection with CHIKV-nLuc at MOI 0.05, with parallel ATP-based cell viability measurements confirming no significant cytotoxicity at tested concentrations.	42531898

In Vitro

MDOLL-0591 (0.003-100 μM) potently inhibits ADP-ribosyl binding activity of the purified CHIKV nsP3 macrodomain with an IC₅₀ of 10 μM^[1].
MDOLL-0591 (12.5-50 μM; 16 h) inhibits CHIKV replication in BHK-21 cells in vitro in a concentration-dependent manner, reducing viral replication by nearly 70% at 50 μM without causing cytotoxicity^[1].
MDOLL-0591 (12.5-50 μM; 20 h) potently inhibits CHIKV replication in HEK-293T cells with an EC₅₀ of 0.5 μM, reducing viral replication by 97% at 50 μM without causing cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 379.43
Formula C₂₀H₁₇N₃O₃S
SMILES

O=C(N1C(C)=C(C)C2=C1C=CC3=CC=CC=C23)CSC4=NC(O)=CC(O)=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Duong MTH, et al. Discovery of thiobarbiturate-indole scaffold as a selective inhibitor targeting chikungunya virus nsP3 macrodomain through a cryptic binding pocket. European journal of medicinal chemistry. 2026 Jul 22;318:119182.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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