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Cat. No.: HY-179696

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Microtubule destabilizing agent-3, negative control

destabilizing agent-3 (HY-179695). Microtubule destabilizing agent-3 is a microtubule destabilizing agent. Microtubule destabilizing agent-3 exerts its antimyeloma phenotypes by destabilizing microtubules and promoting mitotic arrest, leading to cell death. Microtubule destabilizing agent-3 induces G2/M phase arrest and caspase-dependent apoptosis.

For research use only. We do not sell to patients.

CAS No.: 2734582-91-1
Formula: C₁₇H₁₈N₄S
Molecular Weight:310.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Microtubule destabilizing agent-3, negative control Chemical Structure

CAS No.: 2734582-91-1

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Description

In Vitro

Microtubule destabilizing agent-3, negative control (VPR4) does not show thermal stability to DCAF1 in CETSA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2734582-91-1
Molecular Weight 310.42
Formula C₁₇H₁₈N₄S
SMILES

C1(/C=N\NC2=NC=NC3=C2C4CCCCC4S3)=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Susanto O, et al. Discovery and characterisation of VPRBP/DCAF1 kinase inhibitor analogues as microtubular destabilising agents with potent anti-myeloma activity. Mol Cancer Ther. 2025 Nov 4. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Microtubule destabilizing agent-3, negative control

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Microtubule destabilizing agent-3, negative control

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Microtubule destabilizing agent-3, negative control Related Classifications

HY-179696 Related Classifications