ML 145 (Standard)
ML 145 (Standard) is the analytical standard of ML 145 (HY-107536). This product is intended for research and analytical applications. ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM). ML 145 has no significant activity for GPR35 at either rodent ortholog.
For research use only. We do not sell to patients.
- CAS No.: 1164500-72-4
- Formula: C24H22N2O5S2
- Molecular Weight:482.57
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-107536
ML 145GPR35 Antagonist -
HY-107537
CID 2745687GPR35 Antagonist -
HY-B1816
ZaprinastPDE5 Inhibitor -
HY-W008613
Pamoic acidGPR35 Agonist -
HY-W010907
Pamoic acid disodiumGPR35 Agonist -
HY-107512
Kynurenic acid sodiumGPR35 Agonist -
HY-16711
SB225002CXCR2 Antagonist -
HY-15319
AMG 487CXCR3 Antagonist -
HY-15251
ReparixinCXCR1/2 Inhibitor -
HY-10198
NavarixinCXCR1/2 Antagonist -
HY-15589
GW9508GPR40 Agonist -
HY-19855
AZD-5069CXCR2 Antagonist
Biological Activity
Description
IC50 & Target
IC50/EC50: 20.1 nM (GPR35), 21.7 μM (GPR55)[1]
Chemical Information
-
CAS No. 1164500-72-4
-
Molecular Weight 482.57
-
Formula C24H22N2O5S2
-
SMILES
CC(/C=C(S1)/C(N(CCCC(NC2=CC(O)=C(C(O)=O)C=C2)=O)C1=S)=O)=C\C3=CC=CC=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Heynen-Genel S, et al. Selective GPR35 Antagonists - Probes 1 & 2. National Center for Biotechnology Information (US); 2010-2010 Feb 28. [Content Brief]
[2]. Laura Jenkins, et al. Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J Pharmacol Exp Ther. 2012 Dec;343(3):683-95. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ML 145 (Standard) Related Classifications
HY-107536R Related Classifications
Powered by Bioz