MONNA
Based on 1 Customer Validation
MONNA is a potent transmembrane protein 16A (TMEM16A, Anoctamin-1) blocker with an IC50 of 80 nM. MONNA induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
For research use only. We do not sell to patients.
- Purity : 99.13%
- CAS No.: 1572936-83-4
- Formula: C18H14N2O5
- Molecular Weight:338.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Emidurdar (Standard)Reference Standard
Biological Activity
Description
Chemical Information
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CAS No. 1572936-83-4
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Appearance Solid
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Molecular Weight 338.31
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Formula C18H14N2O5
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Color Brown to dark brown
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SMILES
O=C(O)C1=CC([N+]([O-])=O)=CC=C1NC2=CC(OC)=C3C=CC=CC3=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 55.56 mg/mL (164.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Membrane Protein Extraction Using Detergents and Chaotropes
Membrane protein extraction with detergents and chaotropes solubilizes lipid-bilayer-associated proteins by disrupting protein-lipid and protein-protein interactions while maintaining proteins in a soluble state for downstream electrophoresis, purification, or mass spectrometry. Chaotropes such as urea and thiourea improve solubilization of difficult proteins, while nonionic and zwitterionic detergents such as CHAPS, ASB-14, SB 3-10, MEGA-10, dodecyl maltoside, and Triton X-100 differ in extraction efficiency depending on sample type and membrane protein properties.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9559 mL | 14.7793 mL | 29.5587 mL | 73.8967 mL |
| 5 mM | 0.5912 mL | 2.9559 mL | 5.9117 mL | 14.7793 mL | |
| 10 mM | 0.2956 mL | 1.4779 mL | 2.9559 mL | 7.3897 mL | |
| 15 mM | 0.1971 mL | 0.9853 mL | 1.9706 mL | 4.9264 mL | |
| 20 mM | 0.1478 mL | 0.7390 mL | 1.4779 mL | 3.6948 mL | |
| 25 mM | 0.1182 mL | 0.5912 mL | 1.1823 mL | 2.9559 mL | |
| 30 mM | 0.0985 mL | 0.4926 mL | 0.9853 mL | 2.4632 mL | |
| 40 mM | 0.0739 mL | 0.3695 mL | 0.7390 mL | 1.8474 mL | |
| 50 mM | 0.0591 mL | 0.2956 mL | 0.5912 mL | 1.4779 mL | |
| 60 mM | 0.0493 mL | 0.2463 mL | 0.4926 mL | 1.2316 mL | |
| 80 mM | 0.0369 mL | 0.1847 mL | 0.3695 mL | 0.9237 mL | |
| 100 mM | 0.0296 mL | 0.1478 mL | 0.2956 mL | 0.7390 mL |
MONNA Related Classifications
HY-100613 Related Classifications
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