(Mor-Cor)Ag(III) 

(Mor-Cor)Ag(III) is a blood-brain barrier-penetrant silver(III) corrole complex that penetrates the blood-brain barrier. (Mor-Cor)Ag(III) scavenges reactive oxygen species induced by Aβ42 and disrupts Aβ42 aggregation, attenuating Aβ42-induced neuronal hyperactivity. (Mor-Cor)Ag(III) can be used for the research of Alzheimer's disease^[1].

(Mor-Cor)Ag(III) (1, 2 and 6 μM) is non-toxic to HT-22 mouse hippocampal cells at concentrations up to 6 μM, with 1-2 μM being optimal for neuroprotective effects^[1].
(Mor-Cor)Ag(III) (2 μM) provides superior neuroprotection to primary rat neuron-astrocyte cultures against Aβ42-induced neurite fragmentation, gliosis, and neurotoxicity compared to (Cor)Ag(III)^[1].
(Mor-Cor)Ag(III) (2 μM) attenuates Aβ1-42-induced hyperexcitability in primary rat cortical neurons^[1].
(Mor-Cor)Ag(III) (2 μM) reduces neuronal death in primary rat neuron-astrocyte cultures exposed to Aβ42 oligomers^[1].
(Mor-Cor)Ag(III) (2 μM) effectively reduces Aβ42-induced ROS levels in primary rat neuron-astrocyte cultures^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Mor-Cor)Ag(III) (200 μg in 100μL; i.v.; single dose or daily for 7 days) provides neuroprotective effects in 3×Tg-AD mice, increasing dendritic density and reducing Aβ42 deposition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

810.65

C₄₅H₃₂AgN₇O₂

N#CC(C=C1)=CC=C1C(C2=CC=C3N2[Ag]4(N(C(C=C5)=C6C7=CC=C(C#N)C=C7)C5=C3C8=CC=C(OCCN9CCOCC9)C=C8)N%10C6=CC=C%10%11)=C%12[N]4=C%11C=C%12

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tarai A, et al. A Blood-Brain Barrier-Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42-Induced Oxidative Stress. Adv Sci (Weinh). 2026;13(8):e15462.  [Content Brief]