(Mor-Cor)Ag(III)
(Mor-Cor)Ag(III) is a blood-brain barrier-penetrant silver(III) corrole complex that penetrates the blood-brain barrier. (Mor-Cor)Ag(III) scavenges reactive oxygen species induced by Aβ42 and disrupts Aβ42 aggregation, attenuating Aβ42-induced neuronal hyperactivity. (Mor-Cor)Ag(III) can be used for the research of Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C45H32AgN7O2
- Molecular Weight:810.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(Mor-Cor)Ag(III) (1, 2 and 6 μM) is non-toxic to HT-22 mouse hippocampal cells at concentrations up to 6 μM, with 1-2 μM being optimal for neuroprotective effects[1].
(Mor-Cor)Ag(III) (2 μM) provides superior neuroprotection to primary rat neuron-astrocyte cultures against Aβ42-induced neurite fragmentation, gliosis, and neurotoxicity compared to (Cor)Ag(III)[1].
(Mor-Cor)Ag(III) (2 μM) attenuates Aβ1-42-induced hyperexcitability in primary rat cortical neurons[1].
(Mor-Cor)Ag(III) (2 μM) reduces neuronal death in primary rat neuron-astrocyte cultures exposed to Aβ42 oligomers[1].
(Mor-Cor)Ag(III) (2 μM) effectively reduces Aβ42-induced ROS levels in primary rat neuron-astrocyte cultures[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Plasma Concentration |
|---|---|---|---|
| Mice[1] | 200 μg | i.v. | 37.2 μg/mL |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3×Tg-AD (APPSwe, tauP301L) (3-6 months old)[1]
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Dosage:200 μg (24-h single dose; 7-day daily dose)
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Administration:i.v.; single dose (24 h); daily (7 consecutive days)
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Result:Increased dendritic density (measured by MAP2 intensity) in the cortex significantly after single 24-h treatment compared to vehicle; Enhanced MAP2 immunoreactivity in the cortex significantly after 7-day daily treatment; Reduced Aβ42 aggregation in both the hippocampus and cortex significantly after 7-day daily treatment.
Chemical Information
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Molecular Weight 810.65
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Formula C45H32AgN7O2
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SMILES
N#CC(C=C1)=CC=C1C(C2=CC=C3N2[Ag]4(N(C(C=C5)=C6C7=CC=C(C#N)C=C7)C5=C3C8=CC=C(OCCN9CCOCC9)C=C8)N%10C6=CC=C%10%11)=C%12[N]4=C%11C=C%12
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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